Allergic Contact Dermatitis Clinical Trial
Official title:
Alteration of the microRNA-126 Expression: a Possible Mechanism in Allergic Contact Dermatitis to Nickel
NCT number | NCT04365140 |
Other study ID # | ACDm126 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | March 1, 2019 |
Est. completion date | November 30, 2019 |
Verified date | April 2020 |
Source | Universidad Autonoma de San Luis Potosí |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Background. Allergic Contact Dermatitis (ACD) is an inflammatory skin disease mediated by
direct contact with allergens as nickel, the most common allergen, that may be related with
epigenetic changes.
Objective. Evaluate the miR-126 expression and its target VCAM-1, in the skin of patients
with ACD to nickel.
Methods. Fifteen patients with positive patch test to nickel were included, and the
expression of miR-126 and VCAM-1 was evaluated by RT-qPCR.
Status | Completed |
Enrollment | 15 |
Est. completion date | November 30, 2019 |
Est. primary completion date | November 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - 18 years of age and older - Epicutaneous Patch Test positive to Nickel - without previous treatment within the previous 4 weeks Exclusion Criteria: - Pregnancy - nursing - menopause - consumption of any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months - coexistence of other dermatoses conditions |
Country | Name | City | State |
---|---|---|---|
Mexico | Dermatology Department. Hospital Central "Dr. Ignacio Morones Prieto" | San Luis Potosí |
Lead Sponsor | Collaborator |
---|---|
Universidad Autonoma de San Luis Potosí |
Mexico,
Ahlström MG, Thyssen JP, Wennervaldt M, Menné T, Johansen JD. Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment. Contact Dermatitis. 2019 Oct;81(4):227-241. doi: 10.1111/cod.13327. Epub 2019 Jul 9. Review. — View Citation
Cerutti C, Edwards LJ, de Vries HE, Sharrack B, Male DK, Romero IA. MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium. Sci Rep. 2017 Mar 30;7:45284. doi: 10.1038/srep45284. — View Citation
Martins LE, Reis VM. Immunopathology of allergic contact dermatitis. An Bras Dermatol. 2011 May-Jun;86(3):419-33. English, Portuguese. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Expression of miR-126 | Relative expression of the miR-126 on skin biopsies from ACD patients | 9 months |
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