All Cause Mortality Clinical Trial
Official title:
Breast and Other Cancers Following X-Rays for Scoliosis
Verified date | July 11, 2019 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background:
Scoliosis is a curving of the spine. It usually happens in girls when they are children and
teens. Doctors often use x-rays to diagnose it. The x-rays give low radiation. This may
increase the risk that those young women get cancer later in life. Researchers want to learn
more about this risk. They will look data that has already been collected.
Objectives:
To study cancer risks of repeated low radiation from x-rays for scoliosis. Also, to study
death risks related to certain scoliosis patient characteristics. These include causes, kinds
of curvature, and kinds of treatment.
Eligibility:
Medical records of women from past scoliosis studies.
Design:
This U.S. Scoliosis Cohort includes more than 5,000 women who were diagnosed between 1912 and
1965.
Data were collected on these women in the 1980s and 1990s. These came from medical records,
radiology log books, and x-ray films. Researchers found out where participants were,
including if they were dead. Some women were given a follow-up questionnaire.
Researchers want to find out where participants are today. They want to identify new deaths
of participants. They want to find out their causes of death. This data will be added to
other databases.
Status | Completed |
Enrollment | 5573 |
Est. completion date | July 11, 2019 |
Est. primary completion date | August 16, 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 50 Years to 95 Years |
Eligibility | - Data Analysis Only |
Country | Name | City | State |
---|---|---|---|
United States | National Cancer Institute (NCI), 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Cancer Institute (NCI) | Social & Scientific Systems Inc. |
United States,
Doody MM, Lonstein JE, Stovall M, Hacker DG, Luckyanov N, Land CE. Breast cancer mortality after diagnostic radiography: findings from the U.S. Scoliosis Cohort Study. Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63. — View Citation
Ronckers CM, Doody MM, Lonstein JE, Stovall M, Land CE. Multiple diagnostic X-rays for spine deformities and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):605-13. doi: 10.1158/1055-9965.EPI-07-2628. — View Citation
Ronckers CM, Land CE, Miller JS, Stovall M, Lonstein JE, Doody MM. Cancer mortality among women frequently exposed to radiographic examinations for spinal disorders. Radiat Res. 2010 Jul;174(1):83-90. doi: 10.1667/RR2022.1. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cancer incidence | Incidence of breast and other cancers. | 1993 | |
Primary | Cancer and other disease mortality | Mortality from cancer and other causes. | 2015 |
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