Alcoholism Clinical Trial
Official title:
Naltrexone: Consummatory Behaviors in Alcoholic Women
This study will assess naltrexone's effectiveness in treating alcoholism in women and provide information on its potential value in treating eating disorders common among alcoholic women. Alcoholic women with and without both eating disorders and depression will be randomly assigned to placebo or naltrexone treatment. Each group will receive behavioral therapy for 12 weeks, with followup 6 months after treatment.
Background: Despite important gender differences in drinking patterns, physiological effects
of alcohol, and co-occurring psychiatric conditions, relatively little is known about the
efficacy of naltrexone for the treatment of alcohol dependence in women. This study
investigated the safety and efficacy of naltrexone in combination with Cognitive Behavioral
Coping Skills Therapy (CBCST) in a sample of alcohol-dependent women, some with comorbid
eating pathology.
Methods: One hundred three women meeting DSM-IV criteria for alcohol dependence (29 with
comorbid eating disturbances) were randomized to receive either naltrexone or placebo for 12
weeks in addition to weekly group CBCST.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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