Ethanol Induces Skeletal Muscle Autophagy

Status Recruiting

Clinical Trial Summary

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Clinical Trial Description

Hypothesis: Ethanol mediated modification of skeletal muscle proteins to form MAA adducts that in turn induce skeletal muscle autophagy. Patients with alcoholic steatosis, hepatitis and cirrhosis (n=10 each) will be recruited from the liver transplant nutrition clinic or the hepatology inpatient service and their body composition quantified using anthropometry, bioelectrical impedance analysis, CT image analysis and DEXA if available. Control Subjects. Controls will be recruited by advertisement. All control subjects will have a normal clinical history, physical examination, and screening chemistries. They will not have any significant medical conditions requiring the use of medications. Their nutritional status within 20% of normal as defined by ideal body weight. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03209791
Study type	Observational
Source	The Cleveland Clinic
Contact	Revathi Penumatsa, MPH
Phone	2164450688
Email	penumar@ccf.org
Status	Recruiting
Phase
Start date	May 18, 2015
Completion date	December 31, 2025

View Details

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