Risk Factors for Stress-induced Alcohol Misuse: Genetic Predictors and Mediation by Personality Type

Alcohol Use, Unspecified Clinical Trial

— RISK  

Official title:

Personality and Genotypic Markers That Predict Individual Differences in Susceptibility to Stress-induced Alcohol Misuse: a Feasibility Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04533802
• Other study ID #: PHT/2019/63
• Status: Completed
• Start date: August 26, 2020
• Est. completion date: September 30, 2022

Study information

• Verified date: January 2023
• Source: Portsmouth Hospitals NHS Trust
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.

Description:

Alcohol misuse is a global health issue responsible for over 1 million hospital admissions per annum in the UK with a combined cost of approximately £21 billion. Chronic alcohol misuse in patients who attend hospital for alcohol-related illness/injury is common, with relapse and recidivism almost ubiquitous. Patients often report that 'stress' was a catalyst for their drinking episodes, but we do not know exactly who is most at risk, how stress leads to drinking, or the genetic basis for this risk. This research aims to seek to identify patients at higher risk of stress-induced alcohol misuse, or who are more resilient to stress in this context, using a combination of analyses ranging from genetic variants to personality tests and clinical follow-up. The ultimate goal is that patients engaging with alcohol services can receive personalised and focussed treatment and enhance recovery

Recruitment information / eligibility

• Status: Completed
• Enrollment: 29
• Est. completion date: September 30, 2022
• Est. primary completion date: September 30, 2022
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Male or Female, aged (min) 18 years

• Attended Portsmouth Hospitals University Trust following illness/injury related to alcohol use

• Has a maximum AUDIT score of 15

• Is willing and able to comply with study procedures

• Willing and able to give informed consent for participation in the study.

• Must be recruited within 24 hrs of ASNS referral, and able to be tested within 48 hours of referral

Exclusion Criteria:

ny reported/suspected intellectual/learning disabilities (e.g., Down's Syndrome), neurodevelopmental disorders (e.g., Autism, Asperger's) or acquired brain injury

• Has previously participated in this study

• Should not be under the influence of alcohol during the study (12hrs previous to taking part) - to be determined via breathalyser.

• Any history of advanced liver disease (clinical diagnosis of cirrhosis, jaundice, encephalopathy, ascites, variceal haemorrhage)

Related Conditions & MeSH terms

• Alcohol Drinking
• Alcohol Use, Unspecified

Locations

Country	Name	City	State
United Kingdom	Portsmouth University Hospital	Portsmouth	Hampshire

Sponsors (2)

Lead Sponsor	Collaborator
Portsmouth Hospitals NHS Trust	University of Portsmouth

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Alcohol misuse	Measured using the alcohol use disorders identification test (AUDIT) (higher the score the worse the outcome)	immediately after the procedure
Primary	Recent stressors	Measured using the 30 item Stress Overload Scale questionnaire (higher the score, the worse the outcome)	Immediately after the study visit
Primary	Life Events	Measured using the Life Events Checklist Questionnaire (the higher the score the worse the outcome)	Immediately after the study visit
Primary	Impulse Behaviour	Measured using the the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-P) higher values indicate more impulsive behavior.	Immediately after the study visit
Primary	Risk taking behaviour	Measured by the Stop Signal Reaction Time Task (computer task) which measures the ability to inhibit a planned response	Immediately after the study visit
Primary	Molecular Anaylsis	Cheek swabs will be taken from all participant to carry out genomic DNA analysis	Immediately after the study visit