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The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study

Alcohol Use Disorder (AUD) Clinical Trial

Official title:
Zonisamide for the Treatment of Alcohol Use Disorder in the Addiction Neuroclinical Assessment Framework

Clinical Trial Summary

A phase II randomized, double-blind, placebo-controlled clinical trial (RCT) to evaluate the ability of zonisamide (ZON) to decrease alcohol use among treatment-seeking adults with an alcohol use disorder (AUD).

Clinical Trial Description

This project focuses on the efficacy of a promising pharmacotherapy (ZON) for AUDs using a placebo-controlled design that will rigorously measure alcohol use and medication adherence. Results will guide novel mechanistic targets to better capture the heterogeneity within AUDs. This project will evaluate the ability of ZON to treat the alcohol use disorder. The investigators hypothesize that the group assigned to ZON associated with the standard treatment (ZON+ST) will yield lower rates of biochemically verified alcohol use, fewer self-reported drinks per day, and fewer heavy drinking days during the 12-week treatment and 1-year follow-up periods, relative to the placebo associated with the standard treatment (PLO+ST) group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05134857
Study type Interventional
Source Washington State University
Contact Abigail L Bowen, MS
Phone (425) 736-1354
Email abigail.bowen@wsu.edu
Status Recruiting
Phase Phase 2
Start date January 7, 2022
Completion date August 2025
View Details
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