Separation Versus Integrated Approach in Combining ECMO With CRRT

AKI Clinical Trial

Official title:

Separation Versus Integrated Approach in Combining ECMO With CRRT, a Randomized Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05036616
• Other study ID #: IRB.151/64
• Status: Recruiting
• Start date: April 1, 2021
• Est. completion date: December 31, 2023

Study information

• Verified date: July 2023
• Source: Chulalongkorn University
• Contact: Sasipha tachaboon
• Phone: 6622564000
• Email: sasipha_tac[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This investigation aims to evaluate the filter life time of CRRT membrane and complication of combining ECMO and CRRT.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: December 31, 2023
• Est. primary completion date: December 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

1. > 18 years

2. Refractory acidosis (pH<7.2 or HCO3<15)

3. Refractory volume overload

4. Refractory hyperkalemia (K>6.2mEq/L or EKG change)

5. Anuria or oliguria (urine output <0.5 mL/kg/hr for 6-12hr)

6. High BUN >100 mg/dL or uremic symptom

7. Increase intracranial pressure

Exclusion Criteria:

1. Pregnancy

2. Not use heparin in ECMO

3. Chronic kidney disease with CRRT

4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction

Related Conditions & MeSH terms

• AKI

Intervention

Device:
• Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy

Locations

Country	Name	City	State
Thailand	Sasipha tachaboon	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Chulalongkorn University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Circuit lifetime	The time until a CVVH malfunction was identified	72 hours
Secondary	Cost-Effectiveness	To evaluate the cost utility of CRRT between 2 groups	72 hours