Airway Remodeling Clinical Trial
Official title:
Comparison of Changes in Upper Airway Dimensions With Dexmedetomidine and Propofol in Children Undergoing MRI
NCT number | NCT01505933 |
Other study ID # | 35165 |
Secondary ID | |
Status | Terminated |
Phase | Phase 2 |
First received | |
Last updated | |
Start date | February 2012 |
Est. completion date | April 30, 2019 |
Verified date | July 2019 |
Source | Milton S. Hershey Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Sedation is required in infants and children to successfully complete MRI while maintaining respiratory and hemodynamic stability. Limited access to the patient may pose a safety risk during MRI examination. Therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. Propofol is commonly used for sedation in children in the MRI setting because of its predictability, rapid onset, and offset of action. Dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. The rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.
Status | Terminated |
Enrollment | 24 |
Est. completion date | April 30, 2019 |
Est. primary completion date | December 1, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Years to 5 Years |
Eligibility |
Inclusion Criteria: - Children undergoing MRI brain - Age 2 - 5 yrs - ASA I - II Exclusion Criteria: - OSA - Pathology of upper airway - Craniofacial anomalies - Gastroesophageal reflux - Increased intracranial pressure - Body weight of 20% more than ideal - Contraindication to the use of either drug - Failure to maintain a patent airway during the study |
Country | Name | City | State |
---|---|---|---|
United States | Penn State Hershey Medical Center | Hershey | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Milton S. Hershey Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cross-sectional Area (CSA) of the Upper Airway at the Level of Soft Palate, Base of the Tongue and Tip of the Epiglottis | At each anatomic level, measurements will be obtained during three successive respiratory cycles and values will be averaged. | When expired sevoflurane is 0% during the procedure on an average of 5 - 10 mins after discontinuation of sevoflurane, airway measurements will be done | |
Secondary | Anteroposterior Diameter of the Airway at the Level of Soft Palate, Base of Tongue and Tip of the Epiglottis | At each anatomic level, measurements will be obtained during three successive respiratory cycles and values will be averaged | When the the expired sevoflurane is 0% during the procedure on an average of 5 - 10 min after discontinuation of devoflurane, measurement will be obtained | |
Secondary | Transverse Diameter of the Airway at the Level of Soft Palate, Base of Tongue and Tip of the Epiglottis | At each anatomic level, measurements will be obtained during three successive respiratory cycles and values will be averaged | When the the expired sevoflurane is 0% during the procedure on an average of 5 - 10 min after discontinuation of sevoflurane, measurement will be obtained |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05573919 -
VivAer: A Correlation Between Symptom Scores and Objective Findings
|
N/A | |
Recruiting |
NCT03842839 -
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
|
N/A | |
Completed |
NCT04765761 -
Proseal Laryngeal Mask Airway With or Without Introducer-tool Stabilization for Pressure Controlled Ventilation
|
N/A | |
Recruiting |
NCT06288516 -
BenRalizumab Effect on Airway Remodeling in Severe asTHma
|
Phase 4 | |
Enrolling by invitation |
NCT05692362 -
Measure Airway Compliance by Endobronchial Optical Coherence Tomography
|
||
Not yet recruiting |
NCT06459167 -
Position Intervention to Reduce Hypoxemia in Sedation Patients
|
N/A | |
Completed |
NCT02566291 -
Observational Study With Investigation of Two Second Generation Laryngeal Masks
|
N/A | |
Completed |
NCT01178229 -
Physiotherapy on the Airway of Bruxist Children
|
Phase 1/Phase 2 | |
Completed |
NCT06236971 -
Effect of Lateral Positions on the Shape of Upper Airway
|
||
Recruiting |
NCT05550402 -
Role of Parasympathetic Activity in Mild to Severe Asthma With Fixed Airway Obstruction (PARASMA Study)
|
N/A |