Comparisons of Two Airway Clearance Techniques

Airway Clearance Impairment Clinical Trial

Official title:

Comparison of Two Airway Clearance Techniques by Electrical Impedance Tomography- a Parallel Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06032871
• Other study ID #: IRB2212210081
• Status: Recruiting
• Phase: N/A
• Start date: March 16, 2023
• Est. completion date: June 30, 2024

Study information

• Verified date: September 2023
• Source: Chang Gung University
• Contact: Hui-Ling Lin, PhD
• Phone: +886-32118800
• Email: huiling[@]mail.cgu.edu.tw
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to compare the effectiveness of two airway clearance techniques for patients with ventilator associated pneumonia. The main questions it aim to answer are:

• effect of the therapies on volume changes

• outcome on sputum clearance Participants will receive airway clearance techniques of

• chest physiotherapy

• high frequency chest wall oscillation.

Description:

Sputum can be accumulated in the airways of intubated patients, resulting in recurrent pneumonia. The airway clearance therapy is often utilized with chest physiotherapy or high frequency chest wall oscillation which has become popular for its easy of use and less time consuming to the healthcare workers. The main questions it aim to answer are on effectiveness of the therapies on lung volume changes and sputum clearance by two airway clearance techniques. With the oscillation of entire chest wall, the investigators hypothesize that the high frequency chest wall oscillation is more effectively clear sputum in the distal airways.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: June 30, 2024
• Est. primary completion date: March 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Diagnosed with chronic pulmonary disease

• Diagnosed with ventilator associated pneumonia

• Receive airway clearance therapy

Exclusion Criteria:

• Head injury, spinal injury

• Instable hemodynamics

• Intercranial pressure > 20 cmH2O

• Active hemoptysis

• Empyema

• Eye surgery

• Abdominal distension

• Chest tube insertion

• Active tuberculosis

Related Conditions & MeSH terms

• Airway Clearance Impairment

Intervention

Procedure:
• high frequency chest wall oscillation
Patients receive airway clearance by high frequency chest wall oscillation for 30 minutes twice a day.

Locations

Country	Name	City	State
Taiwan	Chang Gung Memorial Hospital	Taoyuan
Taiwan	Linkou Chang Gung Memorial Hospital	Taoyuan

Sponsors (1)

Lead Sponsor	Collaborator
Hui-Ling Lin

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Rowley DD, Malinowski TP, Di Peppe JL, Sharkey RM, Gochenour DU, Enfield KB. A Randomized Controlled Trial Comparing Two Lung Expansion Therapies After Upper Abdominal Surgery. Respir Care. 2019 Oct;64(10):1181-1192. doi: 10.4187/respcare.06812. Epub 2019 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	end-expiratory lung impedance	Changes of global of impedance of lungs measure by the electrical impedance tomography	Measurement before intervention, 30 after, 1 hour and 2 hours after intervention
Secondary	Weight of secretions	Sputum amount is weighted.	Sputum is collected before intervention, 30 after, 1 hour and 2 hours after intervention