Air Pollution Clinical Trial
Official title:
ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure
Fine particulate matter < 2.5 microns (PM2.5) air pollution is a leading global risk factor for cardiovascular morbidity and mortality. PM2.5 presents a serious ongoing public health threat to patients living in highly-polluted countries (ex: China, India) where air quality is projected to remain extremely poor (far exceeding World Health Organization Air Quality Guidelines) for the foreseeable future. This study reviews the benefits of personal level intervention (wearing N95 respirator) over long term, to prevent clinical events among patients with cardiovascular disease.
CLEANAIR-ACS will be an investigation within ASPIRE, that will test the ability of personal-level intervention (N95 respirators) to improve validated surrogate markers of cardio-metabolic health in patients with a recent Acute Coronary Syndrome (ACS). Patients with ACS are a vulnerable patient population with vulnerability and at risk for future cardiovascular events. This vanguard phase study in Beijing involving patients exposed to high levels of air pollution who have recently sustained an ACS event, is necessary to obtain feasibility data and gather a battery of information allowing for the appropriate design of a larger clinical outcome trial. What is more, positive results would provide critically-important information demonstrating for the first time that it is feasible to "prescribe" the use of these personal protection devices to cardiac patients, and that their usage is capable of translating into demonstrable health benefits (i.e., improved BP and insulin sensitivity) over the long-term. The study hypothesis is that long-term personal-level interventions to reduce exposure to PM2.5 can be feasibly performed for 1-year post-acute coronary syndrome (ACS) and will result in significant improvements in validated surrogate cardiometabolic endpoints predictive of morbidity/mortality. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04830059 -
The Joint Effect of Air Pollution and Exercise on Cognitive Function
|
N/A | |
Completed |
NCT02252302 -
Exercise in Air Pollution and Lung Health in Asthmatics
|
N/A | |
Recruiting |
NCT05323240 -
Health Effects of Repeated Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Volunteers
|
N/A | |
Completed |
NCT03187704 -
Boston Puerto Rican Health Study
|
N/A | |
Completed |
NCT03083067 -
Salvational Intervention for Reducing AECOPD Under Severe Air Pollution
|
N/A | |
Recruiting |
NCT05718245 -
HEPA, PM2.5, and Cardiometabolic Health
|
N/A | |
Completed |
NCT04029129 -
Reducing Traffic Pollution Exposure Improves Blood Pressure
|
N/A | |
Recruiting |
NCT05423665 -
Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
|
||
Recruiting |
NCT05570552 -
1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh
|
N/A | |
Recruiting |
NCT05867381 -
Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
|
N/A | |
Completed |
NCT03301519 -
Genetics of Beta Cell Failure in Mexican Americans
|
||
Enrolling by invitation |
NCT02652182 -
Short-term Air Pollution Exposure and In-hospital Outcomes in Patients With Acute Myocardial Infraction
|
N/A | |
Recruiting |
NCT04662047 -
The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population
|
||
Recruiting |
NCT05794087 -
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
|
N/A | |
Recruiting |
NCT04725734 -
Air Pollution and Daily Mobility of Pregnant Women Identification of Critical Windows of Exposure
|
||
Completed |
NCT02673775 -
Air Pollution Study: The Effect of Ozone on the Lung
|
N/A | |
Completed |
NCT02027415 -
The Effect of Juice Types on the Responses to Air Pollution
|
N/A | |
Completed |
NCT00808912 -
Does Sildenafil Increase Exercise Performance in Air Pollution?
|
N/A | |
Completed |
NCT04539925 -
Air Pollution Exposure on Acute Coronary Syndrome in Two Cohorts of Industrial and Non-industrial Areas
|
||
Enrolling by invitation |
NCT05843370 -
Modification of Ambient Air Pollution Exposure and Cardiopulmonary Outcomes by Socioeconomic Status and Nutrition
|