Air Pollution Study: The Effect of Ozone on the Lung

Status Completed

Clinical Trial Summary

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Clinical Trial Description

Subjects will be asked to come to the Rutgers EOHSI clinical center (Piscataway, NJ) for 5 study visits. A physical exam to determine eligibility will be done at the first study visit. If the subject is healthy and able to produce a sputum sample, he/she will then be scheduled for 2 3-hour exposure visits. One exposure will be to clean air and the other exposure will be to 0.2 ppm ozone. During the exposures, subjects will be requested to ride an exercise bicycle intermittently (approximately every 15 minutes). A follow-up visit for sputum collection will be scheduled either 24, 48, or 72 hours after each exposure visit. Blood, urine, and exhaled breath samples will also be collected at each visit. ;

Study Design

Related Conditions & MeSH terms

Air Pollution

Clinical Trial Details

NCT number	NCT02673775
Study type	Interventional
Source	Rutgers, The State University of New Jersey
Contact
Status	Completed
Phase	N/A
Start date	February 2016
Completion date	June 7, 2022

View Details

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