Air Pollution Clinical Trial
Official title:
Effects of Oral Nitrate Supplementation on Vascular and Pulmonary Oxidative Stress Markers Following Traffic Pollution Exposure
Verified date | December 2017 |
Source | Rutgers, The State University of New Jersey |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike. Each subject will be asked to do this twice. Before one car ride, the subject will be asked to drink orange juice. Before the other car ride, the subject will be asked to drink beet juice. Samples of blood and exhaled breath will be collected before, immediately after, and 24 hours after each car ride. Levels of nitrites/nitrates will be measured in the blood and breath.
Status | Completed |
Enrollment | 24 |
Est. completion date | October 2014 |
Est. primary completion date | October 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Healthy - Must live within 20 miles of Piscataway, NJ Exclusion Criteria: - • Are a current smoker - Are pregnant or breastfeeding - Are HIV-positive - Have an active medical condition such as high blood pressure, asthma, diabetes or other serious disease - Have a heart condition such as atrial flutter, atrial fibrillation or a pacemaker - Are unable to ride comfortably in a car for 2 hours - Travel to the EOHSI (Environmental and Occupational Health Sciences Institute) Clinic Center on major highways for more than 3 miles (the Garden State Parkway, the New Jersey Turnpike, Routes 287, 1, 18, or 9). |
Country | Name | City | State |
---|---|---|---|
United States | Environmental and Occupational Health Sciences Institute | Piscataway | New Jersey |
Lead Sponsor | Collaborator |
---|---|
Rutgers, The State University of New Jersey |
United States,
Hussain S, Laumbach R, Coleman J, Youssef H, Kelly-McNeil K, Ohman-Strickland P, Zhang J, Kipen H. Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. J Occup Environ Med. 2012 Oct;54(10):1186-91. doi: 10.1097/JOM.0b013e31826bb64c. — View Citation
Laumbach RJ, Kipen HM. Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways. Ann N Y Acad Sci. 2010 Aug;1203:107-12. doi: 10.1111/j.1749-6632.2010.05604.x. — View Citation
Laumbach RJ, Rich DQ, Gandhi S, Amorosa L, Schneider S, Zhang J, Ohman-Strickland P, Gong J, Lelyanov O, Kipen HM. Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure. J Occup Environ Med. 2010 Mar;52(3):324-31. doi: 10.1097/JOM.0b013e3181d241fa. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in plasma nitrite concentration | Change in plasma nitrite concentration pre- and post-occlusion | Prior to the car ride, immediately after the 2-hour car ride, and 24 hours later | |
Secondary | Change in nitrite/nitrate concentration in exhaled breath | Change in nitrite/nitrate concentration in exhaled breath | Prior to the car ride, immediately after the 2 hour car ride and 24 hours later |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
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