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Treatment of PD-1 Inhibitor in AIDS-associated PML — TPAP  

AIDS Clinical Trial

Official title:
The Effect and Safety of Programmed Cell Death Protein 1 (PD-1) Inhibitor on AIDS Patients With Progressive Multifocal Leukoencephalopathy (PML): A One-center, Single-arm and Prospective Study

Clinical Trial Summary

PD-1 inhibitor （Pembrolizumab, 2mg/kg weight, once per 4 weeks and 3 times of medication usage）treatment on AIDS patients with progressive multifocal leukoencephalopathy.

Clinical Trial Description

This is a one-center, single-arm and prospective study, planing recruiting 10 AIDS-associated PML patients. All patients will receive PD-1 inhibitor (Pembrolizumab) for 12 weeks, and the dose for each time is 2 mg per kg/weight, and the frequency is once per 4 weeks. The effect and safety of Pembrolizumab on AIDS-associated PML will be evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04091932
Study type Interventional
Source First Affiliated Hospital of Zhejiang University
Contact Biao Zhu, PhD
Phone 13906535457
Email zhubiao1207@zju.edu.cn
Status Recruiting
Phase Phase 2
Start date August 20, 2019
Completion date December 2021
View Details
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