AIDS Clinical Trial
Official title:
Cerebral Toxoplasmosis and AIDS in the French Departments of America (DFA). Diagnostic Contribution of a PCR Assay and Genetic Diversity of Toxoplasma Gondii.
With a HIV incidence much higher in the DFA than in European French territory, this disease
is a major public health problem in these areas, especially in French Guiana.
Cerebral toxoplasmosis is a priority among the opportunistic infections in AIDS patients from
the DFA because of its frequency (French West Indies) and of its lethality (French Guiana).
The diagnosis of cerebral toxoplasmosis may be difficult because based only on presumptive
clinical and radiological features. The response to specific antitoxoplasmic therapy confirms
a posteriori the diagnosis.
In reference to the data collected by the Biological Resource Centre Toxoplasma, in
particular in French Guiana, we think that T. gondii strains reactivating in AIDS patients
from DFA are genetically different from those reactivating in AIDS patients from Europe, with
an increased capacity for dissemination via peripheral blood in the first ones. This more
frequent or more prolonged parasitemia could facilitate the diagnosis of cerebral
toxoplasmosis by PCR test from peripheral blood samples in AIDS patients from the French
departments of America.
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