AIDS/HIV PROBLEM Clinical Trial
Official title:
Rapid Oral Test for Therapeutic Response in HIV/AIDS Patients
This study has been designed to evaluate a new oral test for therapeutic monitoring of
HIV/AIDS patients that are receiving the combination Anti-Retroviral Therapy (cART). The test
will measure saliva-based Stress Response Profiling(SRP) biomarkers using laboratory assays.
Results of the test will show if HIV/AIDS patients successfully responded to cART.
Preliminary studies showed that SRP biomarkers were strongly increased in cART-unresponsive
AIDS patients. However, the diagnostic accuracy of the oral test, patients will be recruited
to donate saliva: AIDS patients responsive or unresponsive to cART, and controls (acute or
early HIV patients, and HIV-negative patients with hepatitis).
The saliva samples will be used to measure SRP biomarker concentrations. Results will show
whether the biomarker measurements provide accurate and specific diagnostics for ART
response.
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