Aging Well Clinical Trial
Official title:
Home-based Heat Therapy to Improve Functional Capacity and Vascular Health in Older Adults
To test the hypothesis that home-based leg heat therapy improves functional capacity, vascular function, and exercise hyperemia in older adults.
Chronic whole-body heating (i.e., heat therapy) has gained attention as a novel strategy to improve clinical and physiological outcomes in a number of populations. However, whole-body heat therapy is quite uncomfortable and may require trained personnel to ensure participant safety, especially for those more at risk for heat-related illness. Moreover, the applicability and acceptability of whole-body heat therapy are questionable as equipment cost is substantial and adherence will be low if individuals are required to travel if they cannot afford in-home therapy. Home-based leg heat therapy offers an opportunity to leverage the demonstrated benefits of whole-body heat therapy while managing safety and convenience. The hypothesis will be addressed in the following Specific Aims: Aim 1: Determine the extent to which home-based leg heat therapy improves functional capacity in older adults. Functional capacity will be assessed before and after heat therapy or sham intervention via the 6-min walk test and the Short Physical Performance Battery. Aim 2: Determine if home-based leg heat therapy improves vascular function and exercise hyperemia in the older adults of Aim 1. Using state-of-the-art techniques of skeletal muscle microdialysis and high-resolution duplex ultrasound, the investigators will pharmacodissect mechanisms of vascular function and exercise hyperemia before and after each intervention. The outcomes of Aim 2, while providing insight into the mechanisms whereby heat therapy improves functional capacity, should be considered independent of the outcomes of Aim 1 given that vascular health is a key independent, yet modifiable risk factor for cardiovascular morbidity and mortality. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT06040554 -
The Effect Of A Resistance Exercise Program On Balance Of Elderly People
|
N/A | |
Recruiting |
NCT04518423 -
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
|
||
Recruiting |
NCT05071326 -
Healthy Lifetime - Sustainability and Quality Study
|
N/A | |
Completed |
NCT05135819 -
Cyber School for Grandparents: an Intergenerational Educational Program
|
N/A | |
Recruiting |
NCT05573646 -
Online Group-based Dual-task Training to Improve Cognitive Function of Community-dwelling Older Adults
|
N/A | |
Terminated |
NCT05024903 -
A Novel E-health Platform
|
Phase 2/Phase 3 | |
Completed |
NCT04156074 -
Innovative Food Structures to Enhance Nutrient Bioavailability
|
N/A | |
Withdrawn |
NCT04842864 -
Time Course for Fasting-induced Autophagy in Humans
|
N/A | |
Terminated |
NCT04889131 -
Yoga for Seniors
|
N/A | |
Recruiting |
NCT06085196 -
Mindful Walking Program for Older African Americans
|
N/A | |
Completed |
NCT04828018 -
Care of the Ageing Veteran Population: Developing an Evidence Base for the Royal Hospital Chelsea Model of Care
|
||
Recruiting |
NCT05511259 -
Assessing Causality of the Association Between Exercise and Neurocognitive Gains
|
N/A | |
Completed |
NCT06308458 -
Breather Exerciser Trainer on Diaphragmatic Mobility And Thickness
|
N/A | |
Not yet recruiting |
NCT05001646 -
Electromagnetic Field Protection Device Use Impact in Healthy Volunteers
|
Phase 2 | |
Recruiting |
NCT06219148 -
Music Therapy and Social Work Telehealth for Older Adult Well-Being
|
N/A | |
Not yet recruiting |
NCT06295354 -
Early Variations in Immune Aging
|
||
Not yet recruiting |
NCT04734951 -
Muscle Quality Index Improvement by Exercise and HMB Oral Supplementation in Older Adults
|
N/A | |
Completed |
NCT05456594 -
Comparing Sports Bra Design in Full Busted Women
|
N/A | |
Recruiting |
NCT06217601 -
Impact Evaluation of the Digital Connect Project for Homebound Older Adults
|
N/A | |
Recruiting |
NCT05920733 -
Healthy Lifetime - Phase 2
|
N/A |