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Evaluation of the Functional Results of Bilateral Amygdalotomy for Refractory Aggressive Patients

Aggression Clinical Trial

Official title:
Evaluation of the Functional Results of Bilateral Amygdalotomy for Refractory Aggressive Patients

Clinical Trial Summary

Aggressiveness has a high prevalence in the psychiatry population and is of major concern. Though pharmacological treatments are effective for most patients, there is a portion that doesn't respond properly and is considered medically refractory. For them, surgical procedures (i.e. stereotactic lesions) have been performed as an attempt to reintegrate patient into society. The amygdala is a main structure in the control of aggressive behavior and amygdala lesion could improve behavior without neurological or other behavioral impairment. In this study, it will evaluate the functional results of the bilateral amygdala lesion of aggressive refractory patients through neuroimaging, clinical assessment and blood hormonal levels. To better understand the neurobiology of aggression, aggressive patients that are not refractory will also be studied through neuroimaging and hormonal levels.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03452878
Study type Observational
Source Hospital Sirio-Libanes
Contact
Status Active, not recruiting
Phase
Start date August 6, 2014
Completion date December 31, 2025
View Details
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