The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Aged Clinical Trial

Official title:

The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02761148
• Other study ID #: Z14H180003
• Status: Recruiting
• Phase: N/A
• First received: May 2, 2016
• Last updated: June 10, 2017
• Start date: January 2014
• Est. completion date: December 2019

Study information

• Verified date: June 2017
• Source: Zhejiang University
• Contact: Minming Zhang, Ph.D
• Phone: 13906520711
• Email: zhangminming[@]zju.edu.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: December 2019
• Est. primary completion date: December 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 35 Years to 85 Years

Eligibility

Inclusion criteria:

1. white matter hyperintensity visible on T2 fluid-attenuated inversion recovery images;

2. age between 35 to 80 years;

3. without stroke lesion (except lacunar infarction) on current diffusion weighted images;

4. without a history of multiple sclerosis, Alzheimer's disease, Parkinson's disease and head trauma.

Exclusion criteria:

1. white matter lesions of nonvascular origin (immunological-demyelinating, metabolic, toxic, infectious, other);

2. intracranial hemorrhage;

3. with severe head motion on magnetic resonance images

Related Conditions & MeSH terms

• Aged
• Leukoaraiosis

Locations

Country	Name	City	State
China	The 2nd Affiliated Hospital of Zhejiang University, School of Medicine,	Hangzhou	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fazekas Scale of white matter hyperintensity		1 year
Primary	Mini-Mental State Examination (MMSE)		1 year
Primary	Hamilton Depression Scale (HAMD)		1 year