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NCT03504540 Clinical Trial

Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)

Age Related Macular Degeneration Clinical Trial

— PL-AMD  

Official title:
Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PLAMD)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03504540
Other study ID # MMT_2018_1
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 5, 2018
Est. completion date May 15, 2021

Study information
Verified date May 2021
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients. Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration). The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.

Recruitment information / eligibility
Status Completed
Enrollment 42
Est. completion date May 15, 2021
Est. primary completion date May 15, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria: - Systemic lupus erythematosus - Case patients : with "pseudo-drusen-like" deposit - Control patients : without "pseudo-drusen-like" deposit Exclusion Criteria: - Patient under a measure of legal protection

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Blood test
Blood test for complement factors and genetic polymorphisms of AMD analysis

Locations
Country Name City State
France Fondation ophtalmologique Adolphe de Rothschild Paris

Sponsors (1)
Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Comparison of AMD genetic polymorphisms between case and control patients Baseline
Primary Comparison of complement factors between case and control patients Baseline
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