Flavonoids and Age-related Macular Degeneration

Age-Related Macular Degeneration Clinical Trial

Official title:

Dietary Flavonoids and the Prevalence and 15-year Incidence of Age-related Macular Degeneration in the Blue Mountains Eye Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03407274
• Other study ID #: BMES
• Status: Completed
• Phase: N/A
• First received: January 16, 2018
• Last updated: January 22, 2018
• Start date: January 1992
• Est. completion date: December 2009

Study information

• Verified date: January 2018
• Source: University of Sydney
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study uses 15-year data from the Blue Mountains Eye Study to establish independent associations between dietary intake of total flavonoids and common flavonoid classes with the prevalence and 15-year incidence of age-related macular degeneration (AMD), independent of potential confounders.

Description:

We aimed to use a well characterized large cohort of adults aged 49+ years ( Blue Mountains Eye Study participants) to establish: 1) Associations between dietary intake of total flavonoids with the prevalence and 15-year incidence of age-related macular degeneration (AMD), independent of potential confounders; 2) Prospective relationship between six common flavonoid classes (flavonols, flavan-3-ols, flavones, flavanones, anthocyanins, and isoflavones) and key individual flavonoids (quercetin and hesperidin) with the prevalence and 15-year incidence of AMD; and 3) associations between the main foods and beverages contributing to total flavonoids e.g. tea, apples, oranges and orange juice, and both the prevalence and 15-year incidence of AMD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 3654
• Est. completion date: December 2009
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 49 Years and older

Eligibility

Inclusion Criteria:

• Aged 49+ years and living in two adjoining surban postcode areas in the Blue Mountains area, west of Sydney, in New South Wales, Australia.

Exclusion Criteria:

• Adults aged less than 49 years.

Related Conditions & MeSH terms

• Age-Related Macular Degeneration
• Macular Degeneration

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Sydney

References & Publications (11)

Attebo K, Mitchell P, Smith W. Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996 Mar;103(3):357-64. — View Citation

Gopinath B, Flood VM, Kifley A, Liew G, Mitchell P. Smoking, antioxidant supplementation and dietary intakes among older adults with age-related macular degeneration over 10 years. PLoS One. 2015 Mar 30;10(3):e0122548. doi: 10.1371/journal.pone.0122548. e — View Citation

Gopinath B, Flood VM, Kifley A, Louie JC, Mitchell P. Association Between Carbohydrate Nutrition and Successful Aging Over 10 Years. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1335-40. doi: 10.1093/gerona/glw091. Epub 2016 Jun 1. — View Citation

Gopinath B, Flood VM, Louie JC, Wang JJ, Burlutsky G, Rochtchina E, Mitchell P. Consumption of dairy products and the 15-year incidence of age-related macular degeneration. Br J Nutr. 2014 May;111(9):1673-9. doi: 10.1017/S000711451300408X. Epub 2014 Feb 6 — View Citation

Gopinath B, Liew G, Burlutsky G, Mitchell P. Age-related macular degeneration and risk of total and cause-specific mortality over 15 years. Maturitas. 2016 Feb;84:63-7. doi: 10.1016/j.maturitas.2015.11.001. Epub 2015 Nov 4. — View Citation

Gopinath B, Liew G, Flood VM, Joachim N, Burlutsky G, Mitchell P. Combined influence of poor health behaviours on the prevalence and 15-year incidence of age-related macular degeneration. Sci Rep. 2017 Jun 28;7(1):4359. doi: 10.1038/s41598-017-04697-3. — View Citation

Gopinath B, Liew G, Kifley A, Mitchell P. Thyroid Dysfunction and Ten-Year Incidence of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5273-5277. doi: 10.1167/iovs.16-19735. — View Citation

Gopinath B, McMahon CM, Burlutsky G, Mitchell P. Hearing and vision impairment and the 5-year incidence of falls in older adults. Age Ageing. 2016 May;45(3):409-14. doi: 10.1093/ageing/afw022. Epub 2016 Mar 5. — View Citation

Mitchell P, Cumming RG, Attebo K, Panchapakesan J. Prevalence of cataract in Australia: the Blue Mountains eye study. Ophthalmology. 1997 Apr;104(4):581-8. — View Citation

Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology. 1995 Oct;102(10):1450-60. Review. — View Citation

Smith W, Mitchell P, Leeder SR. Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol. 1996 Dec;114(12):1518-23. — View Citation

* Note: There are 11 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of age-related macular degeneration (AMD)	AMD was assessed from retinal photographs from 1992-4 to 2007-9	15 years