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Prophylactic Ranibizumab for Exudative Age-related Macular Degeneration — PREVENT  

Age-related Macular Degeneration Clinical Trial

Official title:
Prophylactic Ranibizumab for Exudative Age-related Macular Degeneration (AMD) in Vulnerable Eyes With Nonexudative AMD Trial: A Multicenter, Prospectively Randomized, Masked and Controlled, Interventional Investigator Sponsored Phase I/II Study

Clinical Trial Summary

This study will determine whether quarterly injections of Ranibizumab may prevent eyes with dry age-related macular degeneration from progressing to wet age-related macular degeneration (AMD).

Clinical Trial Description

This is a multicenter, prospectively randomized, masked and controlled, interventional investigator sponsored phase I/II study of subjects with high-risk nonexudative age-related macular degeneration (AMD) treated with intravitreal ranibizumab quarterly for prophylaxis of conversion to exudative age-related macular degeneration. The objective of this study is to investigate the safety and efficacy of prophylactic anti-vascular endothelial growth factor (VEGF) therapy with ranibizumab to prevent the development of exudative AMD in eyes with high-risk nonexudative AMD. In addition, baseline characteristics of high-risk eyes (fundus features, optical coherence tomography (OCT) parameters and genetic profile) will be evaluated to determine their predictive value in conversion to exudative AMD. The effect of ranibizumab on the atrophic component of AMD will also be monitored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02140151
Study type Interventional
Source Southern California Desert Retina Consultants, MC
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 17, 2014
Completion date July 9, 2020
View Details
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