Age-Related Macular Degeneration Clinical Trial
Official title:
Blood and Saliva Sample Collection and Submission to the Age-Related Eye Disease Study 2 (AREDS2) Genetic Repository
Background:
- The Age-Related Eye Disease Study 2 (AREDS 2) is looking at different eye diseases. Study
participants will provide blood and saliva samples. The samples will be stored for research
on eye diseases.
Objectives:
- To collect blood and saliva samples for AREDS 2 research.
Eligibility:
- AREDS 2 research study participants.
Design:
- Participants will provide blood and saliva samples.
- The samples will be submitted with personal and medical information. This information
will be collected during the AREDS 2 procedures.
AREDS2 is a multi-center, Phase III, randomized clinical trial designed to assess the effects
of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and/or
omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) as a treatment for age-related
macular degeneration (AMD), cataract and moderate vision loss. In addition to this objective,
the AREDS2 study will provide information on the clinical course, prognosis, and risk factors
for development and progression of both AMD and cataract. Other study goals include the
evaluation of eliminating beta-carotene and/or reducing zinc in the original AREDS
formulation on the progression and development of AMD. AREDS2 will also seek to validate the
fundus photographic AMD scale developed from AREDS.
The objective of this protocol is to have AREDS2 participants submit blood and saliva samples
to the AREDS2 Genetic Repository (Fisher BioServices, Rockville, MD) in order to provide
further materials for the study of the genetic and biochemical bases for eye disease and
possibly other diseases.
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