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Afibrinogenemia clinical trials

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NCT ID: NCT01124981 Completed - Clinical trials for Fibrinogen Deficiency in Complex Cardiac Surgery

Haemocomplettan® P During Elective Complex Cardiac Surgery

Start date: February 2011
Phase: Phase 2/Phase 3
Study type: Interventional

Fibrinogen concentrate is increasingly used in cardiac surgery to reverse coagulopathy. Whether its use reduces blood loss, transfusion and occurrence of clinical adverse events remains unknown.

NCT ID: NCT00496262 Completed - Clinical trials for Fibrinogen Deficiency

Human Fibrinogen - Pharmacokinetics

Start date: July 2007
Phase: Phase 2
Study type: Interventional

This study evaluated the single-dose pharmacokinetics of human fibrinogen concentrate and clot strength (maximum clot firmness [MCF]) in subjects with congenital fibrinogen deficiency. MCF was measured to demonstrate the functional activity of replacement fibrinogen when a fixed dose of human fibrinogen concentrate was administered.