Clinical Trials Logo

Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT01475396
Other study ID # Exercise_Neuromod
Secondary ID
Status Active, not recruiting
Phase Phase 3
First received November 7, 2011
Last updated June 18, 2012
Start date March 2006
Est. completion date December 2012

Study information

Verified date June 2012
Source University Hospital Muenster
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Interventional

Clinical Trial Summary

Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 120
Est. completion date December 2012
Est. primary completion date March 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 50 Years to 80 Years
Eligibility Inclusion Criteria:

- 50-80 years old

- healthy

- lesser activity

Exclusion Criteria:

- regular physical activity

- diabetes

- stroke

- heavy smoking, drinking,

- BMI < 20

- MMSE < 25

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Related Conditions & MeSH terms


Intervention

Behavioral:
exercise


Locations

Country Name City State
Germany University Hospital of Muenster Muenster NRW

Sponsors (2)

Lead Sponsor Collaborator
University Hospital Muenster German Federal Ministry of Education and Research

Country where clinical trial is conducted

Germany, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition 6 months No
Primary Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition 6 months No
Primary Change of performance in ms in a reaction time task after 6 months of intervention/control condition 6 months No
Primary Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition 6 months No
Secondary Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition 6 months No
Secondary Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition 6 months No
See also
  Status Clinical Trial Phase
Completed NCT06309654 - Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes N/A
Completed NCT05580263 - Different Order of Concurrent Training on Improving Visceral Adipose Tissue and Insulin Resistance. N/A
Not yet recruiting NCT04121637 - To Investigate the Effect of Aerobic Exercise on Neurophysiological Values and Functionality in Individuals With Multiple Sclerosis. N/A
Completed NCT02541136 - Neural Changes of Exercise: a Functional MRI Study N/A
Recruiting NCT06084455 - TMS-evoked Potentials During Aerobic Exercise N/A
Completed NCT04288830 - Evaluation of a Tai Chi Resilience Training Program on Objective and Subjective Measures of Post Traumatic Stress Disorder Severity N/A
Active, not recruiting NCT06105697 - Effects of Aerobic Blood Flow Restriction N/A
Completed NCT04068285 - Neuromuscular Adaptations to Exercise In Patients With Type 2 Diabetes Mellitus N/A
Recruiting NCT06152614 - MIND Foods and Aerobic Training in Black Adults With HTN N/A
Completed NCT04856280 - Kinesiological Taping and Aerobic Exercise in Women With Primary Dysmenorrhea: N/A
Recruiting NCT02648945 - Effects of Low and High Intensity Exercise in Improving Working Memory Among Students With Anxiety Symptoms N/A
Completed NCT02327975 - Prescription of Physical Exercise Through Mobile Application in Elderly N/A
Completed NCT03759509 - Effects of Aerobic Exercise Training on Nurses' Sleep Quality, Fatigue, Attention and Cortisol Profile N/A
Completed NCT05987436 - Effect of Aerobic Exercise in Patients With Essential Hypertension
Completed NCT05839743 - Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients N/A
Not yet recruiting NCT06413940 - Exploring the Clinical Efficacy of Remote Management Applications Through Comprehensive Physical Therapy for Patients With Moderate to Severe Sleep Apnea N/A
Completed NCT05235958 - VascuFit: Exercise and Vascular Aging N/A
Enrolling by invitation NCT05352334 - Comparison of High Intensity Interval Training Verses Aerobic Exercises on Emotional Intelligence of University Students N/A
Terminated NCT01644812 - Lifestyle Interventions for Generalized Anxiety Disorder N/A
Recruiting NCT06217068 - Comparative Analysis of Biomarkers in Response to Acute Moderate-Intensity Activity Phase 1/Phase 2