A Study of Sirolimus for Injection (Albumin Bound) in Patients With Advanced Solid Tumors

Advanced Solid Tumors Clinical Trial

Official title:

A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Antitumor Activity of Sirolimus for Injection (Albumin Bound) in Patients With Advanced Solid Tumors

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05125523
• Other study ID #: HB1901-CSP-001
• Status: Recruiting
• Phase: Phase 1
• Start date: December 28, 2021
• Est. completion date: November 2024

Study information

• Verified date: November 2021
• Source: CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
• Contact: Xuekun Yao
• Phone: 0311-67808678
• Email: yaoxuekun[@]mail.ecspc.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to estimate the safety, tolerability, pharmacokinetics (PK), and antitumor activity of Sirolimus for Injection (Albumin Bound) in patients with solid malignancies.

Description:

This study will be conducted in two stages.

Stage 1: To evaluate the safety and tolerability of Sirolimus for Injection (Albumin Bound) in patients with advanced tumors, determine the MTD and RP2D. The dose escalation scheme using the accelerated titration design for dose 1 and the rolling-six design for the remaining doses.

Stage 2: To preliminarily assess the antitumor activity of Sirolimus for Injection (Albumin Bound). Patients will be assigned to different cohorts based on their tumor type.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 264
• Est. completion date: November 2024
• Est. primary completion date: June 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Age 18-75 years (inclusive), no gender limitation.

2. Patients must have a histologically or cytologically confirmed advanced or metastatic tumor for which no effective standard therapy is available, or have failed or been intolerant to standard therapies.

3. At least one measurable lesion per RECIST version 1.1.

4. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 to 2.

5. Life expectancy of =3 months.

6. Suitable organs and hematopoietic function should be available. Laboratory tests during screening should meet the appropriate criteria.

7. Signed informed consent form.

Exclusion Criteria:

1. Prior anticancer treatment or participation in another clinical study within 4 weeks (or 5 half-lives of the treated drug, whichever is longer) prior to the first dose of study drugs.

2. Patients who have undergone major surgery within 4 weeks prior to starting study treatment, or who have not fully recovered from previous surgery.

3. Unresolved toxicities from prior therapy greater than Grade 1 as per Common Terminology Criteria for Adverse Events (CTCAE) (except alopecia or any other toxicity without safety risks as judged by the investigator).

4. History of serious cardiovascular disease.

5. Central nervous system metastasis or meningeal metastasis with clinical symptoms, or other evidence that the patient's central nervous system metastasis or meningeal metastasis has not been controlled, and the investigator judges it to be unsuitable for inclusion.

6. Known prior hypersensitivity to study drugs or any component in their formulations.

7. Prior treatment with any mTOR inhibitor.

8. Has received a live or live-attenuated virus vaccine within 30 days prior to consent.

9. Uncontrollable active infection (CTCAE v5.0 =grade 2).

10. Use of strong inhibitors and inducers of CYP3A4 within 2 weeks prior to receiving the first dose of study drug and still need to continue using this class of drug.

11. History of autoimmune diseases, immunodeficiency, including HIV positive, or other acquired, congenital immunodeficiency, or organ transplant history.

12. HBsAg-positive with HBV viral load (VL) =1000 IU/mL; Hepatitis C Virus (HCV)-positive; Anti-treponema pallidum positive.

13. Women of child-bearing potential, or men whose partners are women of childbearing age, have not agree to use highly effective methods of contraception during dosing and for 6 months after study drug discontinuation; female patients has a positive serum pregnancy test within 7 days prior to receiving the first dose of study medication; lactating female.

14. Has history of other serious diseases judged by the investigator, which will threaten the safety of patients or interfere the study compliance, or other reasons are not suitable for participating in the study.

Related Conditions & MeSH terms

• Advanced Solid Tumors
• Neoplasms

Intervention

Drug:
• Sirolimus for Injection (Albumin Bound)
Sirolimus for Injection (Albumin Bound), intravenously, once a week, 28 days per cycle (three weeks-on and one week-off)

Locations

Country	Name	City	State
China	Tianjin Medical University Cancer Institute and Hospital	Tianjin	Tianjin

Sponsors (1)

Lead Sponsor	Collaborator
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with adverse events		Up to 3 years
Primary	Dose-Limiting Toxicities (Stage 1)		Cycle 1 (Up to 28 days)
Primary	Maximum tolerated dose (Stage 1)		Up to 1.5 years
Primary	Recommended phase 2 dose (Stage 1)		Up to 1.5 years
Primary	Overall response rate (Stage 2)		Up to 3 years
Secondary	Area under the plasma concentration versus time curve (AUC)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Peak concentration (Cmax)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Peak time (Tmax)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Distribution volume (Vz)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Elimination half-life (t1/2)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Clearance (CL)		Day 1 of cycle 1 to Day 1 of cycle 4 (85 days)
Secondary	Disease Control Rate		Up to 3 years
Secondary	Duration of Response		Up to 3 years
Secondary	Progression-free Survival		Up to 3 years
Secondary	4ebp-1 phosphorylation level in blood samples		Up to 168 hours post dose
Secondary	S6K phosphorylation level in blood samples		Up to 168 hours post dose
Secondary	TSC1/2 status in tumor samples		Day 1 of cycle 1
Secondary	PTEN status in tumor samples		Day 1 of cycle 1
Secondary	PIK3CA status in tumor samples		Day 1 of cycle 1