Advanced Solid Tumor Clinical Trial
Official title:
Combining Epigenetic And Immune Therapy to Beat Cancer. CAIRE Study
Umbrella study structure to independently and simultaneously assess the effects of the association of durvalumab and tazemetostat in multiple solid tumors.
4 independant, multicenter, prospective, signle-arm phase II trials, based on 2-stage Simon's optimal design, will be conducted in parallel to assess the efficacy of durvalumab when prescribed with tazemetostat, separately, in distinct cohorts of solid tumors: - cohort A: patients with pancreatic cancer - cohort B: patients with colorectal cancer not MSI-H or MMR-deficient - cohort C: patients with metastatic solid tumors with positive interferon gamma signature and/or tertiary lymphoid structure positive - cohort D: patients with soft-tissue sarcoma ;
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|---|---|---|---|
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