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Safety and Early Signs of Efficacy of IL12-L19L19. — DODEKA  

Advanced Solid Tumor Clinical Trial

Official title:
A Phase I Study to Evaluate Safety and Early Signs of Efficacy of the Human Monoclonal Antibody-cytokine Fusion Protein IL12-L19L19.

Clinical Trial Summary

The purpose of this study is to describe the safety, tolerability and early signs of efficacy of the antibody-cytokine fusion protein IL12-L19L19 in patients with advanced or metastatic solid carcinomas, after previous immune checkpoint blockade therapy. The primary objective of the study is to evaluate the safety of IL12-L19L19 and to establish MTD in order to establish a recommended dose (RD). The secondary objectives of the study are to assess early signs of efficacy, the determination of pharmacokinetic (PK) properties and the immunogenicity of IL12-L19L19.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04471987
Study type Interventional
Source Philogen S.p.A.
Contact Jacqueline Mock, PhD
Phone +41 798708167
Email regulatory@philogen.com
Status Recruiting
Phase Phase 1
Start date July 1, 2020
Completion date December 2025
View Details
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