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Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Advanced Solid Tumor Clinical Trial

Official title:
A Phase 1, Open-label, Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Clinical Trial Summary

This is a phase 1, multi-center, open-label, dose-escalation study of nab-sirolimus in adult patients with locally advanced or metastatic solid tumors and moderate hepatic impairment or normal hepatic function.

Clinical Trial Description

This is a phase 1, multi-center, open-label, dose-escalation study of nab-sirolimus in adult patients with locally advanced or metastatic solid tumors and moderate hepatic impairment or normal hepatic function. Eligible patients will receive nab-sirolimus by intravenous (IV) infusion over 30 minutes (+10 min) on Days 1 and 8. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05661461
Study type Interventional
Source Aadi Bioscience, Inc.
Contact Aadi Medical Information
Phone 1-888-246-2234
Email MedInfo@aadibio.com
Status Recruiting
Phase Phase 1
Start date November 23, 2022
Completion date April 1, 2025
View Details
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