Advanced/Metastatic Solid Tumors Clinical Trial
Official title:
A First-in-Human (FIH), Open-Label, Phase 1/2 Dose Escalation and Expansion Study of ADG126, ADG126 in Combination With Anti PD1 Antibody, and ADG126 in Combination With ADG106 in Patients With Advanced/Metastatic Solid Tumors
ADG126, ADG126 in Combination with anti-PD1 antibody, and ADG126 in Combination with ADG106 in Patients with Advanced/Metastatic Solid Tumors .
ADG126 is a novel anti-CTLA-4 fully human IgG1 antibody prodrug that is modified with Adagene Safebody technology to control the activation of anti-CTLA4 activity.ADG106 is a fully human ligand-blocking, agonistic anti-CD137 IgG4 mAb which is expected to enhance the activity of activated T cells. The enhanced antitumor efficacy results observed from the preclinical studies of ADG126 in combination with ADG106 or anti-PD-1 provided further support to explore such combinations in clinical settings for better patient responses. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05514444 -
Study of MK-4464 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced/Metastatic Solid Tumors (MK-4464-001)
|
Phase 1 | |
| Active, not recruiting |
NCT04501276 -
A Phase 1b/2 Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients
|
Phase 1 | |
| Active, not recruiting |
NCT04182516 -
Study of NMS-03305293 in Pts With Selected Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Terminated |
NCT00996255 -
Dose-Escalation Study of PHA-793887 in Patients With Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Terminated |
NCT02444793 -
A Study of PF-05082566 In Combination With Mogamulizumab In Patients With Advanced Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT03526835 -
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05718895 -
A Study of ATG-022 in Patients With Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Completed |
NCT03833427 -
Study of Selumetinib (MK-5618) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (MK-5618-001)
|
Phase 1 | |
| Recruiting |
NCT05607498 -
First in Human Study of EMB-07 in Locally Advanced/Metastatic Solid Tumors or Relapse/Refractory Lymphoma
|
Phase 1 | |
| Recruiting |
NCT05405595 -
ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT02665416 -
Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors
|
Phase 1 | |
| Terminated |
NCT01092052 -
Study of NMS-1116354 in Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Completed |
NCT05277402 -
ADG116 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT05614258 -
Study of ADG206 in Subjects With Advanced/Metastatic Solid Tumors
|
Phase 1 | |
| Active, not recruiting |
NCT05394168 -
A Phase I Clinical Study of HLX53 in Advanced/Metastatic Solid Tumors
|
Phase 1 |