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Advanced Cancer clinical trials

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NCT ID: NCT04303091 Completed - Multiple Myeloma Clinical Trials

The Feasibility of a Physical Activity Intervention for Advanced Multiple Myeloma Patients

Start date: March 2, 2018
Phase: N/A
Study type: Interventional

Although physical activity (PA) is commonly used to manage symptoms and enhance quality of life (QOL) in cancer survivors, relatively little is known regarding the benefits in advanced multiple myeloma (MM). The primary aims of the Physical Activity in Advanced Cancer Treatment (PAACT) intervention were to examine (1) program feasibility and (2) potential impact on patient outcomes. It is hypothesized that an exercise intervention will be feasible and potentially impactful.

NCT ID: NCT04257617 Completed - Advanced Cancer Clinical Trials

A Trial of ZL-1201 in Subjects With Advanced Cancer

Start date: May 11, 2020
Phase: Phase 1
Study type: Interventional

First in Human, Phase I Trial of ZL-1201 in Subjects with Advanced Cancer

NCT ID: NCT04254926 Completed - Advanced Cancer Clinical Trials

Impact of a Resource-based Life Review Intervention on Advanced Cancer Patients

Revie?
Start date: April 6, 2019
Phase: N/A
Study type: Interventional

The main objective of the present study is to evaluate the effects of the Revie ⊕ intervention on the self-esteem of patients diagnosed with an advanced cancer. A pragmatic, two-arm parallel-group, waitlist randomized controlled trial is conducted. The study takes place in the oncology department of the University Hospitals of Geneva at 3 outpatient units.

NCT ID: NCT04200963 Completed - Neoplasms Clinical Trials

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Start date: December 18, 2019
Phase: Phase 1
Study type: Interventional

This study will be conducted in adult subjects diagnosed with any form of an advanced or metastatic solid tumors including urothelial carcinoma for which standard therapy is no longer effective or is intolerable. This is a phase 1, multi-center, open label study designed to assess safety and tolerability of IK-175 as a single agent and in combination with nivolumab, to determine the recommended phase 2 dose (RP2D). Disease response, pharmacokinetics (PK), pharmacodynamics, and response biomarkers will also be assessed.

NCT ID: NCT04193319 Completed - Advanced Cancer Clinical Trials

Effect of Fluconazole on PK of Fluzoparib in Healthy Male Subjects

Start date: July 19, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the Effect of fluconazole on the Pharmacokinetics of Fluzoparib in Healthy male Adults

NCT ID: NCT04149704 Completed - Advanced Cancer Clinical Trials

Videos for Advance Care Planning in Young Adults

Start date: December 13, 2019
Phase: N/A
Study type: Interventional

This study is a randomized trial of adolescent and young adults with advanced cancer and their caregivers to assess preferences for care in advanced cancer. This research study is examining the similarities and differences between patient's and caregiver's goals of cancer care. The names of the study interventions involved in this study may include: - Questionnaires - Video - Phone Interview

NCT ID: NCT04148937 Completed - Advanced Cancer Clinical Trials

A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer

Start date: January 16, 2020
Phase: Phase 1
Study type: Interventional

The reason for this study is to see if the CD73 inhibitor LY3475070 alone or in combination with pembrolizumab is safe and effective in participants with advanced cancer.

NCT ID: NCT04071262 Completed - Advanced Cancer Clinical Trials

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Therapies in Japanese Participants With Advanced Cancer

Start date: December 20, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see if the study drug abemaciclib in combination with other anti-cancer therapies is safe in Japanese participants with advanced cancer.

NCT ID: NCT03980041 Completed - Bladder Cancer Clinical Trials

Study to Evaluate the Efficacy/Safety of IPI-549 in Combination With Nivolumab in Patients With Advanced Urothelial Carcinoma (MARIO-275)

Start date: September 25, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to measure the effect of IPI-549 in combination with nivolumab when compared to nivolumab monotherapy in advanced urothelial cancer patients.

NCT ID: NCT03979118 Completed - Advanced Cancer Clinical Trials

Exercise Prescription in Patients With Bone Metastases

Ex-Met
Start date: October 15, 2019
Phase:
Study type: Observational

Cancer which has spread to the bone, causing bone metastases (bone tumours) can weaken bone health and increase risk of fractures (breaks). Consequently, patients can be unsure whether to exercise and health professionals can be unsure what exercise advice is suitable. Despite this, it is well known that exercise improves quality-of-life for patients with bone metastases and therefore it is important that exercise is prescribed to these patients. This study aims to increase understanding of the link between daily exercise and risk of fracture in patients with bone metastases.