Adult Patients Clinical Trial
— SEVORASSOfficial title:
Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients
Describe the Richmond Agitation Sedation Scale (RASS) values corresponding to the values of Minimum alveolar concentration of sevoflurane during sedation of patients in ICU
Status | Completed |
Enrollment | 30 |
Est. completion date | November 2014 |
Est. primary completion date | November 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Requiring sedation by sevoflurane in ICU - Adult patients - Patients covered by french health care system - Patients who have given their consent or his family Exclusion Criteria: - Pregnant or lactating women - Sevoflurane anaphylaxia - Known or suspected risk of malignant hyperthermia - Refusal Protocol - Brain-damaged patients - Hemodynamic conditions not compatible with the use of sevoflurane - ARDS patients - Minor patients |
Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | CHU Clermont-Ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Description of the RASS score | Describe the RASS score corresponding to the values of sevoflurane MAC during sedation of patients in ICU : RASS score determined at the middle of each level of 30 minutes, each level correspond to determined sevoflurane MAC with ascending MAC ranging from 0 to 0.8 and then descending MAC from 0.8 to 0. | at day 1 | No |
Secondary | determination of the associated hemodynamic and respiratory parameters | Determine the associated hemodynamic and respiratory parameters, bispectral index and analgesia-nociception index for each level of sevoflurane MAC (monitored at the middle of each level of 30 minutes). | at day 1 | No |
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