Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery

Adult Cardiac Surgery Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02407574
• Other study ID #: FFR2015
• Status: Not yet recruiting
• Phase: N/A
• First received: March 24, 2015
• Last updated: March 30, 2015
• Start date: May 2015

Study information

• Verified date: March 2015
• Source: University Hospital of Liege
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 20
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• CABG only surgery

• Preopeartive LVEF = 53 %

• Use of epicardial pacing wires to assist CPB weaning

Exclusion Criteria:

• Contra-indication to TEE

• AV block at the time of CPB weaning

• Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Adult Cardiac Surgery

Intervention

Device:
• External Pacing Box
Atrial pacing using an external pacing box

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital of Liege

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	End-systolic elastane of the left ventricle.		30 minutes after CPB weaning	No