Adrenocortical Carcinoma Clinical Trial
Official title:
Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research trial studies genes in samples from younger patients with
adrenocortical tumor.
OBJECTIVES:
- To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation
status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs)
analysis in pediatric adrenocortical tumors and compare those results to those of the
same patient's normal cells.
OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep
sequencing, micro RNA , methylation status, copy variation, and single-nucleotide
polymorphisms. Results are then compared with patients' normal cells.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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