Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?

Status Terminated

Clinical Trial Summary

Inhaled corticosteroids are largely used in patients with asthma or chronic obstructive lung diseases. The purpose of this study is to determine if the use of inhaled corticosteroids is associated with suppression of endogenous cortisol production, as seen in patients treated with pharmacologic doses of oral or parenteral steroids.

Clinical Trial Description

The normalcy of the hypothalmic-pituitary-adrenal (HPA) axis of enrolled subjects will be assessed by low dose (1mcg) corticotropin (ACTH)stimulation test. Serum cortisol levels will be measured before , 30 minutes and 60 minutes after 1 mcg ACTH intravenous injection. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Adrenal Insufficiency

Clinical Trial Details

NCT number	NCT00560625
Study type	Observational
Source	HaEmek Medical Center, Israel
Contact
Status	Terminated
Phase	N/A
Start date	May 2007
Completion date	December 2008

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT03282487` - Optimising Steroid Replacement in Patients With Adrenal Insufficiency	Phase 4
Not yet recruiting	`NCT06435481` - Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatrics	Phase 4
Not yet recruiting	`NCT05716607` - Treatment Study in Patients Treated With Both Insulin & Hydrocortisone	N/A
Recruiting	`NCT03399383` - Adherence in Chronic Adrenal Insufficiency	N/A
Completed	`NCT01428336` - Value of 25 mcg Cortrosyn Stimulation Test	N/A
Completed	`NCT00851942` - Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test	Phase 4
Withdrawn	`NCT00368381` - Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis	Phase 4
Active, not recruiting	`NCT04519580` - Improved Diagnostics and Monitoring of Polymyalgia Rheumatica
Recruiting	`NCT06008184` - Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Completed	`NCT03013166` - THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone
Enrolling by invitation	`NCT02282150` - Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism	Phase 4
Completed	`NCT02934399` - Dynamic Hormone Diagnostics in Endocrine Disease
Completed	`NCT03000231` - Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency
Completed	`NCT01960530` - An Investigational Study of Hydrocortisone	Phase 1
Completed	`NCT00552487` - Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis	N/A
Completed	`NCT00575341` - Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency	Phase 3
Completed	`NCT00471900` - Six Months DHEA Treatment in Female Adrenal Failure	N/A
Completed	`NCT03294876` - Rheumatoid Arthritis Adrenal Recovery Study
Completed	`NCT03709381` - Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study	Early Phase 1
Recruiting	`NCT05639127` - The Treatment of Adrenal Crisis With Inhaled Prednisolone	Early Phase 1