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Clinical Trial Summary

Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team. The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO. This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT06182319
Study type Interventional
Source University of California, Los Angeles
Contact Steven Stokes
Phone 310-206-7436
Email sstokes@mednet.ucla.edu
Status Recruiting
Phase Phase 3
Start date January 1, 2024
Completion date December 15, 2025

See also
  Status Clinical Trial Phase
Recruiting NCT04318821 - Effect of Laser Acupuncture on Adhesive Small Bowel Obstruction N/A
Active, not recruiting NCT01867528 - Comparison of Laparoscopic Surgery Versus Open Surgery in the Treatment of Adhesive Small Bowel Obstruction N/A
Completed NCT03602352 - A Study of the Cost for Patients Operated for Adhesive Obstruction (SBO) During a Five-year Period
Completed NCT03534596 - Surgery for Adhesive Small Bowel Obstruction in a Defined Population: a Cohort Study