Study of ADHD Children's Sensitivity to Memory Error Production

ADHD Clinical Trial

— TDAH-DRM  

Official title:

Sensitivity of Children With Attention Deficit/Hyperactivity Disorder to Memory Error Production

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05365295
• Other study ID #: 49RC22-0095
• Status: Completed
• Phase: N/A
• Start date: June 28, 2022
• Est. completion date: October 17, 2022

Study information

• Verified date: October 2022
• Source: University Hospital, Angers
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of the study is to test whether children with Attention Deficit/Hyperactivity Disorder (ADHD) are more susceptible to false memory production using a DRM paradigm. The number of "critical decoy production" errors will be analyzed and compared to the calibration of the test.

Description:

During a neuropsychological assessment, as part of the clinical routine, children with a diagnosis of ADHD, without neurological etiology, aged 8 to 10 years will be offered an additional task. This task, a DRM adapted to the child, consists of learning several lists of words. Each list exposes words belonging to the same lexical field, to a concept not explicitly mentioned in the list, called critical lure. Immediately after the presentation of a list, the child is asked to recall as many words as possible. Recall of the critical lure gives an indication of the production of false memories. The number of critical lures produced by these children will be compared to the calibration of the test, currently being published. The investigator will also verify if the production of critical lures can be correlated with other variables such as performance on intellectual, executive and attentional tasks, proposed during the clinical routine assessment.

The investigator hypothesize that ADHD children will recall more critical lures than the norm, and fewer correct responses than the norm.

The data collected is taken from the child's psychological file. The only personal information used, beyond test performance, is the child's gender and age. The procedure is anonymous.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: October 17, 2022
• Est. primary completion date: October 17, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 96 Months to 131 Months

Eligibility

Inclusion Criteria:

• Age between 96 and 131 months

• Child referred by a doctor for a neuropsychological assessment

• Child with ADHD diagnosis

• Sufficient command of the French language

• Non-opposition of the child and his/her parents

Exclusion Criteria:

• Severe psychiatric comorbidity: major depressive episode, bipolar disorder, generalized anxiety disorder, autism spectrum disorder

• Major neurological history: severe head trauma, stroke, severe epilepsy, brain tumor

• Repeating a class during school

• Presence of an intellectual disability

• Use of methylphenidate treatment less than 48 hours before the experiment

• Completion of an intellectual assessment using the Wechsler Intelligence Scale for Children (WISC-V) dated less than one year before the meeting

Related Conditions & MeSH terms

• ADHD
• Hypersensitivity

Intervention

Other:
• DRM (Deese, Roediger et McDermott task)
Eight lists of nine words are presented to the participants. Each list is heard once. Immediately afterwards, the child is asked to recall the words he or she remembers. Each child's response is then repeated one by one and the participant is asked to rate his or her confidence in the response on a five-point scale (from "not at all sure" to "100% sure"). A 5-minute break is given in the middle of the task, after the first four lists are presented. The test takes about 20 minutes.

Locations

Country	Name	City	State
France	neuropediatrics department - university hospital center of Angers	Angers
France	Multidisciplinary liberal practice - Acropole Santé	Rezé

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Angers

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DRM (Deese-Roediger-McDermott task) Performance 1	correct answers	20 minutes during DRM DRM (Deese-Roediger-McDermott) task
Primary	DRM (Deese-Roediger-McDermott task) Performance 2	critical lures	20 minutes during DRM DRM (Deese-Roediger-McDermott) task
Primary	DRM (Deese-Roediger-McDermott task) Performance 3	intruders associated with the lexical field	20 minutes during DRM DRM (Deese-Roediger-McDermott) task
Primary	DRM (Deese-Roediger-McDermott task) Performance 4	non-associated intruders	20 minutes during DRM DRM (Deese-Roediger-McDermott) task
Primary	DRM (Deese-Roediger-McDermott task) Performance 5	average confidence index for each type of answer	20 minutes during DRM DRM (Deese-Roediger-McDermott) task