Target ADHD Executive Working Memory Study

ADHD Clinical Trial

Official title: Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training

Status Completed

Clinical Trial Summary

This study will assess whether or not a novel executive working memory training intervention for Attention-Deficit/Hyperactivity Disorder can engage frontoparietal brain network treatment targets and behavioral performance.

Clinical Trial Description

This proposal seeks support for a 2-year milestone-driven R61 initial test of target engagement in n=62 ADHD diagnosed adolescents randomized to a 'sham training' placebo or to train 4 times each week using 4 different EWM exercises that have been combined into the format of a typical cognitive training intervention. Exercise difficulty levels in the active intervention will increase across 5 weeks to continually challenge EWM ability. EWM training will use a novel, remotely-supervised 'at home' computerized training approach. If R61 EWM training target engagement milestones are met, a 3-year R33 phase will begin. The R33 will replicate target engagement in another randomized placebo-controlled trial of n=90 new ADHD adolescents and attempt to establish a convincing link between the hypothesized targets and ADHD symptom expression. It also will characterize ADHD brain activity or EWM ability changes relative to typical levels seen in an n=40 non-ADHD control group. ;

Related Conditions & MeSH terms

• ADHD

• NCT number: NCT04795674
• Study type: Interventional
• Source: Hartford Hospital
• Status: Completed
• Phase: N/A
• Start date: November 1, 2021
• Completion date: March 19, 2023