ADHD Clinical Trial
Official title:
Placebo-Controlled Trial With GlyTI-M Among Children With ADHD
Although psychostimulant is the first line of drug to treat Attention Deficit Hyperactivity Disorder, (ADHD), actually there are 10-20% ADHD patient do not response well to current medication. Most of parents of children with ADHD in Taiwan dislike to use psychostimulant. We expect that GlyTI-M will have better efficacy than placebo to reduce ADHD symptoms. This study will also help us to understand the mechanism of ADHD and give a way to develop new drug and also a more possible way to treat ADHD children under 6 years old.
The accumulated neuro-image, hereditary and animal studies showed the correlation between
glutamate transport dysfunction and ADHD psychopathology. However, there is limited clinical
trial to testify the effect of modulating the NMDA receptor function of glutamate to treat
ADHD.
GlyTI-M is an endogenous Glycine transporter I inhibitor, and it acts on the glutamatergic
synapse to modulate the neurotransmission of N-Methyl-D-Aspertate (NMDA) receptor. This
study aims to explore the effect of GlyTI-M among children with ADHD.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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