ADHD Clinical Trial
Official title:
Methylphenidate Treatment of Children and Adolescents Diagnosed With ADHD and Its Influence on Comorbid Trichotillomania
This study will evaluate the safety and effectiveness of methylphenidate in treating
attention deficit hyperactivity disorder (ADHD) in children with both ADHD and
trichotillomania.
Trichotillomania is an impulse control disorder. There is growing evidences of the
involvement of dopaminergic neurotransmission in the pathophysiology of trichotillomania.
Reported increase in the prevalence of ADHD among patients with impulse control disorders,
such as pathological gambling as well as trichotillomania, may result from the overlapping
pathophisiological background. It is hypothesized that in cases of ADHD comorbid with
trichotillomania methtylphenidate treatment will exhibit beneficial effects in both the ADHD
and the hair pulling.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | October 2009 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 6 Years to 18 Years |
Eligibility |
Inclusion Criteria: - DSM-IV Diagnosis of trichotillomania - DSM-IV diagnosis of ADHD - Has not taken stimulants or alpha-adrenergic medications for more than 2 weeks prior to entering the study. Exclusion Criteria: - History of moderate or severe adverse event, related to MPH - History of any psychotic disorder - Current drug abuse, acute psychotic or affective disorder |
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Israel | Geha Mental Health Center | Petah Tikva |
Lead Sponsor | Collaborator |
---|---|
Geha Mental Health Center | Clalit Health Services |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinicial administered Massachusetts General Hospital Hair Pulling Scale for trichotillomania | First 6 weeks of treatment | ||
Secondary | Clinicial administered ADHD Rating Scale Clinical Global Impressions (CGI) scale for ADHD severity Weekly spontaneous self report of side effects | Within the first 6 weeks of treatment |
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