A Double-Blind Comparison of Galantamine HBr and Placebo in Adults With Attention Deficit Hyperactivity Disorder

ADHD Clinical Trial

Official title:

A Double-Blind Comparison of Galantamine HBr and Placebo in Adults With Attention Deficit Hyperactivity Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00181675
• Other study ID #: 2002-P-001937
• Status: Completed
• Phase: Phase 4
• First received: September 12, 2005
• Last updated: July 22, 2010
• Start date: December 2002
• Est. completion date: September 2003

Study information

• Verified date: July 2010
• Source: Massachusetts General Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This will be a double-blind, placebo-controlled, study using daily doses of up to 24 mg/ day Galantamine HBr in the treatment of adults who meet DSM-IV criteria for childhood-onset ADHD. Specific hypotheses are as follows:

Hypothesis 1: ADHD symptomatology in adults with DSM-IV ADHD will be responsive to acute Galantamine HBr treatment.

Hypothesis 2: Galantamine HBr -associated improvement in ADHD symptomatology in adults will translate into improved functional capacities (neuropsychological, social, and occupational) as well as an increased quality of life throughout acute treatment.

Hypothesis 3: Galantamine HBr treatment will be safe and well tolerated as reflected by a low drop out rate and absence of major differences from placebo.

Description:

Galantamine HBr, a tertiary alkaloid, is a competitive and reversible inhibitor of acetylcholinesterase that is indicated to slow the deterioration of cognitive impairment in Alzheimer's Disease. Initial anecdotal data suggest a promising role for Galantamine HBr in the treatment of ADHD. We propose to study to test the safety and efficacy of Galantamine HBr therapy in adults with ADHD. We will test if Galantamine HBr -associated improvements in ADHD symptomatology translate into improved cognitive and functional capacities (social and occupational) as well as increased quality of life.

The proposed study includes 1) use of a 12-week design to document the response rate 2) assessment of the impact of Galantamine HBr on functional capacities (quality of life, psychosocial function) and cognition, 3) careful assessment of safety and tolerability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: September 2003
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 58 Years

Eligibility

Inclusion Criteria:

1. Male outpatients between 18 to 58 years of age (inclusive).

2. Females between 18 to 58 years of age (inclusive) that are on reliable and adequate birth control.

3. Subjects with the DSM-IV diagnosis of childhood onset Attention-Deficit/Hyperactivity Disorder (ADHD), as manifested in the clinical evaluation and confirmed by structured interview.

4. Subjects with a score of 24 or greater on the ADHD Rating Scale.

Exclusion Criteria:

1. Any current, non-ADHD Axis I psychiatric condition of clinical significance.

2. Baseline Ham-D > 16, BDI > 19, and/or Ham-A > 21.

3. Any clinically significant chronic medical condition, specifically cardiovascular, gastrointestinal, pulmonary, genitourinary, metabolic, or endocrine disorders, and hepatic or renal impairment.

4. Clinically significant abnormal baseline laboratory values.

5. I.Q. <75.

6. Organic brain disorders.

7. Subjects with a history of or current seizure disorders.

8. Pregnant and/or nursing females.

9. Clinically unstable psychiatric conditions (i.e. suicidal behaviors, psychosis).

10. Subjects currently (within the past 6 months) known to abuse or to be dependent on any drug, including alcohol.

11. Subjects on other psychotropic medications, with the exception of SSRIs.

12. Subjects with a history of intolerance or non-response to cholinergic agents as determined by the clinician.

13. Subjects with a history of peptic ulcer disease, gastroesophageal reflux disease, or other GI disorders.

14. Subjects with history of bradyarrythmias.

15. Subjects with asthma.

16. Subjects on ketoconazole.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• ADHD
• Attention Deficit Disorder with Hyperactivity

Intervention

Drug:
• galantamine HBr

Locations

Country	Name	City	State
United States	Massachusetts General Hospital	Cambridge	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Massachusetts General Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	symptom reduction using ADHD- Clinical Global Impression & ADHD Symptom Checklist Severity Scale administered weekly