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Adenomyosis clinical trials

View clinical trials related to Adenomyosis.

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NCT ID: NCT06373822 Recruiting - Adenomyosis Clinical Trials

New Perspectives in Adenomyosis Pathogenesis With Epigenetic Analysis and miRNAs

ADENO-MIRNA
Start date: March 21, 2024
Phase:
Study type: Observational

Objectives: To identify differentially expressed miRNAs in the blood of adenomyosis patients in view to develop new diagnostic methods Hypotheses Circulating miRNAs may be abnormally expressed in patients suffering from adenomyosis and could be used to diagnose the disease Study Design Blood samples will be collected from healthy subjects and adenomyosis patients and miRNAs will be isolated and analyzed to detect potential differences.

NCT ID: NCT06239376 Recruiting - IVF Clinical Trials

Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients

FET-ADE
Start date: February 19, 2024
Phase: N/A
Study type: Interventional

This randomized clinical trial aims to assess the comparative effectiveness of two distinct endometrial preparation protocols for frozen embryo transfer (FET) among women with adenomyosis undergoing IVF/ICSI. Specifically, it seeks to address the following key questions: 1. Does the protocol involving the combination of GnRH agonist and letrozole for down regulation with exogenous steroids (GnRHa+AI - AC) result in a higher live birth rate compared to the use of exogenous steroids alone (AC) in women with adenomyosis undergoing frozen embryo transfer? 2. What are the common side effects of the GnRHa+AI - AC regimen? Eligible participants will undergo screening before endometrial preparation for FET, following which they will be randomly assigned to one of two groups: GnRHa+AI - AC or AC. In the GnRHa+AI - AC group, participants will be pre-treated with GnRH agonist and letrozole two months before endometrial preparation. After this period, participants will return for endometrial preparation, and any side effects resulting from the down regulation will be evaluated. In contrast, the AC group will receive standard treatment.

NCT ID: NCT06211569 Recruiting - Clinical trials for Elective Fertility Preservation

Study of the Prevalence of Endometriosis and Adenomyosis

PrevADEOSE
Start date: April 4, 2024
Phase:
Study type: Observational

Our study aims to assess the prevalence of adenomyosis and endometriosis in patients consulting for elective fertility preservation through the diagnosis of these pathologies by transvaginal pelvic ultrasound. Imaging data will be compared with clinical data (patient characteristics, clinical symptoms) as well as the assessment of anxiety, depression, and quality of life collected from the women.

NCT ID: NCT06123975 Recruiting - Adenomyosis Clinical Trials

Adenomyosis Patients With Infertility and Immunological Factors

Start date: March 1, 2024
Phase:
Study type: Observational

Infertile patients with adenomyosis who met the inclusion and exclusion criteria, after signing the informed consent form, the researchers recorded the clinical information of the patients and initiated the in vitro fertilization-embryo transfer (IVF-ET) procedure. Peripheral blood was collected on the day of embryo transfer. And if the pregnancy test was positive at 14 days after embryo transfer, peripheral blood was collected at 21 days after the transfer and every 2 weeks thereafter until 12 weeks of gestation. By analyzing the changes of immune cells and molecules in the peripheral blood of the patients, role of immune factors in infertility combined with adenomyosis was further explored.

NCT ID: NCT06117410 Recruiting - Ultrasound Clinical Trials

Assessing Ultrasonographic Severity of Adenomyosis

AdenoStaging
Start date: February 8, 2021
Phase:
Study type: Observational

The aim of this pilot study is to develop a feasible and quantifiable ultrasonographic method to grade the severity of adenomyosis and to determine the interobserver variation.

NCT ID: NCT06043583 Recruiting - Adenomyosis Clinical Trials

Intrauterine Device Versus Uterine Artery Embolization for Adenomyosis

Start date: July 21, 2023
Phase: N/A
Study type: Interventional

The primary purpose of this study is to compare the therapeutic efficacy of intrauterine device and uterine artery embolization for uterine adenomyosis.

NCT ID: NCT05937490 Recruiting - Adenomyosis Clinical Trials

Adenomyosis and ART

ADENOFERT
Start date: March 27, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to: - Prospectively investigate the association of Adenomyosis with fertility outcomes in relation to COH protocols for ART (long or ultra- long protocol) with a preventive high-dose anti-inflammatory progestin such as DNG and to assess their association with pregnancy and neonatal outcomes (preterm delivery,pre-eclampsia,Caesarean section,fetal malpresentation,small for gestational age,low birth weight and postpartum hemorrhage). - Understand how the endometrial interface by studying the response of progesterone and DNG stimulated decidualization markers, correlating them with the success of ART protocol stimulation and to pregnancy specific outcomes - Evaluate the immune changes during the implantation period and in the different trimesters of the pregnancies after ART conception.

NCT ID: NCT05505656 Recruiting - Adenomyosis Clinical Trials

Accuracy of Endomyometrial Biopsy in Diagnosis of Adenomyosis

Start date: June 9, 2022
Phase:
Study type: Observational

This study will compare the accuracy of diagnosing adenomyosis by obtaining hysteroscopic guided endomyometrial biopsy and comparing it to accuracy of diagnosis by transvaginal ultrasound and magnetic resonance imaging.

NCT ID: NCT05153928 Recruiting - Clinical trials for Abnormal Uterine Bleeding

Management of Uterine Leiomyomata and Adenomyosis

Start date: April 10, 2021
Phase:
Study type: Observational

1. to determine the role of hysteroscopy and guided biopsy to differentiate between submucosal fibroids and adenomyosis confirmed by histopathological examination 2. to evaluate the efficacy of norethisterone in the treatment of symptomatic adenomyosis and leiomyoma

NCT ID: NCT05152667 Recruiting - IVF Clinical Trials

Ambispective Study to Assess the Effect of Pretreatment With a Levonorgestrel-Releasing Intrauterine System Versus Oral Progestin

Start date: November 27, 2021
Phase:
Study type: Observational

The study participants' relevant medical records will be collected and reviewed for the retrospective subjects and after obtaining informed consent for the prospective subjects. The study materials that will be used will include blood tests, transvaginal ultrasound and magnetic resonance imaging (MRI). The study will involve two study arms