Personalised Therapy for Metastatic ADPC Determined by Genetic Testing and Avatar Model Generation

Adenocarcinoma Clinical Trial

— AVATAR  

Official title:

Personalised Therapy for Patients With Metastatic Adenocarcinoma of the Pancreas Determined by Genetic Testing and Avatar Model Generation

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02795650
• Other study ID #: 2015-004860-12
• Status: Active, not recruiting
• Phase: Phase 2
• Start date: May 2016
• Est. completion date: September 2022

Study information

• Verified date: February 2021
• Source: Hospital Universitario de Fuenlabrada
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a multicenter, open label, randomised phase II clinical trial for patients with metastatic adenocarcinoma of the pancreas. Patients randomised to the experimental arm will undergone tumoral biopsy before starting first line of treatment and will be administered personalised therapy as second or third line.

Description:

This is a multicenter, open label, randomised phase II clinical trial for patients with metastatic adenocarcinoma of the pancreas. Patients with metastatic disease will be randomised to the experimental or control arms. Those in the experimental arm will undergone a tumoral biopsy in order to perform exome sequencing, bioinformatic report, and avatar mouse models for drug testing. This information will allow the expertise panel to elaborate a treatment recommendation as second or third lines of treatment. Patients in the control arm will receive treatment as per investigator´s judge. The main objective of the trial is to determine whether personalised treatments achieve improved 1-year overall survival.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 146
• Est. completion date: September 2022
• Est. primary completion date: September 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Histologically or cytologically confirmed diagnosis of adenocarcinoma of the pancreas.
• ECOG performance status 0 or 1
• Age = 18 years old.
• Willingness of male and female subjects, who are not surgically sterile or postmenopausal, to use reliable methods of birth control (oral contraceptives, intrauterine devices, or barrier methods used with a spermicide) for the duration of the study.
• One or more sites of metastasis with one of the susceptible of biopsy.
• Measurable or evaluable disease
• No prior treatment with radiotherapy, surgery, chemotherapy or investigational treatment for the metastatic disease or no more than the three cycles of first line chemotherapy. Palliative radiotherapy for bone metastasis is allowed. Adjuvant or neoadjuvant radiotherapy or chemotherapy are allowed if they finished more that 6 months ago and the patient has no remaining toxicities.
• Bone marrow function as follows, no more than 14 days prior to randomisation:

ANC > 1,500 cells/mm3 Platelets > 100,000 cells/mm3 Hemoglobin =9 g/dl

• Adequate liver, renal and bone marrow functions.
• AST (SGOT), ALT (SGPT) = 2.5 × ULN and = 5 x ULN if liver metastases.
• Bilirubin = 1,5 x ULN
• Albumin total = 0,75 ULN
• Creatinine = 1,5 x ULN
• Ability to sign informed consent
• Patients will be allowed to be randomised just once.

Exclusion Criteria:

• Brain metastases, unless they have been previously treated and stable for 3 months at least (defined as no oedema, no need of steroids and stable disease in two CT scans separated by a minimum of 4 weeks).
• Locally advanced disease.
• Malignancies other than pancreatic cancer diagnosed within 5 years prior to randomization, except for adequately treated carcinoma in situ or basal or squamous cell skin cancer.
• Bacterial, viral or fungal active infection that require systemic treatment.
• Any contraindication for tumor biopsy.
• Past or present HIV or hepatitis B or C infection.
• Severe medical problems affecting organs or psychiatric illnesses that could interfere with the safety of the patient in the trial.
• Pregnancy or breastfeeding women.
• Patient will need to be informed and agree to undergo tumoral biopsy in the experimental arm.

Related Conditions & MeSH terms

• Adenocarcinoma

Intervention

Drug:
• Personalised treatment
Personalised treatments include chemotherapy, targeted therapy, immunotherapy or others based on the previous test results, chosen from a database that include more than 2000 different drugs.
• Treatment chosen per investigator´s judge
Investigators are allowed to chose what they consider the best standard treatment option for their patients.

Locations

Country	Name	City	State
Spain	Hospital Universitario de Fuenlabrada	Fuenlabrada	Madrid
Spain	Hospital Universitario 12 de Octubre	Madrid
Spain	Hospital Universitario de la Paz	Madrid
Spain	Hospital Universitario Ramón y Cajal	Madrid
Spain	Hospital Miguel Servet	Zaragoza

Sponsors (1)

Lead Sponsor	Collaborator
Hospital Universitario de Fuenlabrada

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	1-year overall survival	Efficacy. 1-year overall survival	1-year overall survival