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Effect of Protein Supplementation on Craving in Subjects Hospitalised for Addiction Treatment — CRAVPROT  

Addiction Clinical Trial

Official title:
Effect of Protein Supplementation on Craving in Subjects Hospitalised for Addiction Treatment. Monocentric Pilot Study.

Clinical Trial Summary

Moncentric pilot study conducted in the addictology department of the Pau Hospital, designed to demonstrate the benefit of protein supplementation on craving in patients with a substance use disorder at the start of their treatment for addiction. This study will be conducted according a crossover design with a one-week phase with protein supplementation (P) and a one-week phase without protein supplementation (SP).

Clinical Trial Description

Addiction is a chronic psychiatric disorder characterised by the loss of control over the use of rewarding substances or behaviours, despite the accumulated damage. Craving, defined as an irrepressible, obsessive craving, is a key early symptom of addiction. Protein supplementation could reduce this craving. Nutritional abnormalities aggravate addictions but no study have directly assessed the impact of protein supplementation on craving. Evidence suggests that protein supplementation reduces cravings for sugary and hyperpalatable foods, which could extend to rewarding substances. The hypothesis is that this supplementation reduces the intensity, duration and frequency of craving in withdrawal patients by influencing dopaminergic reward circuits. Protein supplementation takes the form of a powder sachet mixed with yoghurt or compote. It will be given twice a day, at the same time (8am and 4pm). Patients will be enrolled at the admission to the addiction unit. They will be assessed psychologically, addictologically and nutritionally for one week and then will be randomised. Patients will be asked to assess their cravings, dietary needs, consumption of addictive substances and palatable foods. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06459609
Study type Interventional
Source Centre Hospitalier de PAU
Contact Alice SERIS
Phone 0559726997
Email alice.seris@ch-pau.fr
Status Not yet recruiting
Phase N/A
Start date September 1, 2024
Completion date September 1, 2025
View Details
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