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Clinical Trial Summary

The overarching goal of this study is to evaluate the potential of Cannabidiol (CBD) as an adjunctive treatment for comorbid opioid use disorder (OUD) and chronic pain. This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of CBD on measures of pain and opioid craving in outpatients with OUD receiving medication-assisted treatment (MAT) with methadone or buprenorphine.


Clinical Trial Description

An initial safety pilot phase will recruit six participants: three receiving treatment with methadone and three receiving treatment with buprenorphine. If the results of the pilot study support the safety of CBD administration in this clinical sample, the general study will recruit 48 participants with comorbid OUD and chronic pain, for a total of 24 completers - 12 subjects (6 men and 6 women) receiving methadone and 12 subjects (6 men and 6 women) receiving buprenorphine. Both sub-studies will enroll participants who do not currently require an inpatient hospitalization. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05076370
Study type Interventional
Source Yale University
Contact Joao De Aquino, M.D.
Phone 203-932-5711
Email Joao.deaquino@yale.edu
Status Recruiting
Phase Early Phase 1
Start date December 8, 2021
Completion date July 1, 2024

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