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Acute Spinal Paralysis clinical trials

View clinical trials related to Acute Spinal Paralysis.

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NCT ID: NCT05244408 Recruiting - Clinical trials for Spinal Cord Injuries

"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation

SCRIBBLE
Start date: March 17, 2023
Phase:
Study type: Observational

Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients. Study will also establish the accuracy of point to care devices for SCI blood biomarkers and support the biospecimen collection for the International Spinal Cord Injury Biobank (ISCIB).

NCT ID: NCT03911492 Recruiting - Clinical trials for Spinal Cord Injuries

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

CASPER
Start date: August 31, 2019
Phase: N/A
Study type: Interventional

This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. 1. Determine the effect of SCPP maintenance ≥ 65 mmHg in acute SCI on neurologic recovery as measured by ASIA Impairment Scale (AIS) grade conversion and motor score improvement. 2. Collect CSF and blood samples for the measurement of neurochemical biomarkers and storage for future biomarker discovery and validation studies.