Acute Respiratory Failure Clinical Trial
Official title:
Observational Cohort Study of a National Extracorporeal Membrane Oxygenation Service for Adults With Respiratory Failure: the NHS ECMO Study.
This is an observational study of outcomes of the NHS England-commissioned national
respiratory ECMO service, which has been active at six centres since December 2011.
The primary outcome of interest is the number of patients who survive to ICU discharge at the
ECMO centre. The study also aims to identify factors predictive of outcome.
Recent randomised and observational studies suggest there may be a role for extracorporeal
membrane oxygenation (ECMO) in patients with severe acute respiratory failure that have not
responded to conventional measures.
In 2011, NHS England commissioned a national service to provide ECMO for severe respiratory
failure at six centres across the country. Patients with severe respiratory failure are
referred to the network if conventional measures are unsuccessful, and if accepted are
transferred to an ECMO centre for specialist care. The criteria for admission is at the
discretion of clinicians at each centre.
The NHS ECMO registry has been created by cross-referencing data submitted to the
Extracorporeal Life Support Organisation (ELSO) in Ann Arbor, Michigan, with a tracker
document identifying patients treated within the network. Analysis has been undertaken from
December 2018 to March 2019.
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