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Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines

Acute Respiratory Failure Clinical Trial

Official title:
Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines: an Ancillary Study of the NUTRIREA2 Trial (NCT01802099)

Clinical Trial Summary

To evaluate the impact of enteral nutrition on microaspiration of gastric content and pharyngeal secretions

Clinical Trial Description

A common obstacle to enteral nutrition is gastrointestinal intolerance, with regurgitations potentially responsible for gastric-content aspiration. Several studies involving technetium 99m (99mTc) labeling of gastric contents have established that gastric-fluid microaspiration is common in critically ill patients receiving both endotracheal ventilation and enteral nutrition. However, to our knowledge, no studies have specifically addressed the role for enteral nutrition in the occurrence of microaspiration. The objective of this ancillary study is to compare the frequency of gastric-content microaspiration in patients given enteral versus parenteral nutrition during the NUTRIREA2 trial. The new knowledge of risk factors for microaspiration provided by this study may help to improve strategies for preventing microaspiration and ventilator-associated pneumonia (VAP). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03411447
Study type Interventional
Source Centre Hospitalier Departemental Vendee
Contact
Status Terminated
Phase N/A
Start date January 27, 2015
Completion date July 7, 2015
View Details
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