Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

Acute Respiratory Failure Clinical Trial

Official title:

Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02196870
• Other study ID #: Chest wall Elastance in ARF
• Status: Completed
• Phase: N/A
• First received: July 12, 2014
• Last updated: June 23, 2015
• Start date: July 2014
• Est. completion date: June 2015

Study information

• Verified date: June 2015
• Source: Southeast University, China
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Institutional Ethics Committe of Zhongda hospital, Nanjing
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Description:

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: June 2015
• Est. primary completion date: June 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• ARF

• mechanical ventilation

• cardiovascular stable

Exclusion Criteria:

• age < 18y or > 85y

• pregnancy

• COPD or chronic pulmonary disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Respiratory Failure
• Airway Pressure Stress Index
• Chest Wall Elastance
• Respiratory Distress Syndrome, Adult
• Respiratory Insufficiency
• Transpulmonary Pressure Stress Index

Locations

Country	Name	City	State
China	Zhongda Hospital	Nanjing	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Southeast University, China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes of oxygenation and lung mechanics		up to 24 months	Yes