Study of the Evolution Profile of the Renal Doppler in the Perioperative Hepathic Transplantation

Acute Renal Failure Clinical Trial

— DOP-RENAL  

Official title:

Study of the Evolution Profile of the Renal Doppler in the Perioperative Hepathic Transplantation - Interest in Predicting the Occurence of Acute Postoperative Renal Faillure

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04682236
• Other study ID #: 8059
• Status: Recruiting
• Start date: November 25, 2020
• Est. completion date: May 25, 2022

Study information

• Verified date: December 2020
• Source: University Hospital, Strasbourg, France
• Contact: Julien POTTECHER, MD, PhD
• Phone: 33 3 88 12 70 95
• Email: julien.pottecher[@]chru-strasbourg.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Liver transplantation is associated with a modification of the perfusion pressures of the abdominal organs (preoperative portal hypertension in connection with liver pathology, and normalization of the perfusion pressures during surgery). This abrupt change in the infusion regime is probably responsible for an alteration in renal function in some patients, and the identification of renal vascular profiles using Doppler could point to pathological profiles, which should be diagnosed early.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: May 25, 2022
• Est. primary completion date: May 25, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patient of full age (=18 years)

• Patient operated on at the HUS for a liver transplant, between July 1, 2019 and June 30, 2020.

• Patients having undergone an evaluation of hepatic and renal vascular profiles perioperatively.

• Patients hospitalized in the surgical intensive care unit after hepatic transplant surgery.

• Patient not having expressed, after information, the reuse of his data for the purposes of this research

Exclusion Criteria:

• Patient who expressed his opposition to participating in the study

• Patient with suspected obstructive acute renal failure

• Stenosis of renal arteries known at the time

• End-stage renal disease on dialysis

• Impossibility of giving the subject informed information (difficulties in understanding the subject, etc.)

• Subject under safeguard of justice

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Renal Failure
• Renal Insufficiency

Locations

Country	Name	City	State
France	Strasbourg University Hospitals - Anesthesia-intensive care unit	Strasbourg

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Retrospective analysis of the development profiles of renal dopplers in perioperative liver transplantation		Files analysed retrospectily from July 1st, 2019 to June 30, 2020 will be examined