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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01376531
Other study ID # 837.041.10 2
Secondary ID
Status Completed
Phase N/A
First received June 15, 2011
Last updated April 12, 2013
Start date January 2011
Est. completion date June 2011

Study information

Verified date April 2013
Source Johannes Gutenberg University Mainz
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

The aim of the study is to characterize the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.


Description:

Patients at the intensive care unit who suffered acute renal failure with the need of continuous veno-venous hemodialysis will be investigated with continuous veno-venous hemodialysis and in a time window without continuous veno-venous hemodialysis to investigate the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.


Recruitment information / eligibility

Status Completed
Enrollment 20
Est. completion date June 2011
Est. primary completion date June 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- acute renal failure

- need for continuous veno-venous hemodialysis

- age >18 Years

Exclusion Criteria:

- Sepsis

- Preexisting cerebral illness

- traumatic brain injury

- Meningitis or encephalitis

- Pregnancy

Study Design

Time Perspective: Prospective


Intervention

Procedure:
continuous veno-venous hemodialysis
continuous veno-venous hemodialysis

Locations

Country Name City State
Germany University medical centre Mainz

Sponsors (1)

Lead Sponsor Collaborator
Johannes Gutenberg University Mainz

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Schramm P, Closhen D, Wojciechowski J, Berres M, Klein KU, Bodenstein M, Werner C, Engelhard K. Cerebrovascular autoregulation in critically ill patients during continuous hemodialysis. Can J Anaesth. 2013 Jun;60(6):564-9. doi: 10.1007/s12630-013-9912-z. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Change from Baseline cerebrovascular autoregulation to cerebrovascular autoregulation during continuous veno-venous hemodialysis Is there an influence of continuous veno-venous hemodialysis at the cerebrovascular autoregulation, which would be a side effect with limiting use in patients with brain injury or the need of intensive monitoring of cerebral perfusion pressure in this patients. 1 Year No
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